Bacterial processing of glucose modulates C. elegans lifespan and healthspan
| العنوان: | Bacterial processing of glucose modulates C. elegans lifespan and healthspan |
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| المؤلفون: | Heidi A. Tissenbaum, Yong-Hak Seo, Steven E. Finkel, Samuel F. Kingsley, Krishna S. Ghanta, Calista Allen |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Molecular biology, Science, Longevity, 030106 microbiology, Carnosine, Bacterial Physiological Phenomena, medicine.disease_cause, Article, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Glycation, Escherichia coli, Genetics, medicine, Animals, Caenorhabditis elegans, Symbiosis, Gene, Multidisciplinary, biology, biology.organism_classification, Cell biology, Caenorhabditis, Glucose, 030104 developmental biology, chemistry, biology.protein, Medicine, Energy Metabolism, Bacteria, Oxidative stress |
| الوصف: | Intestinal microbiota play an essential role in the health of a host organism. Here, we define how commensal Escherichia coli (E. coli) alters its host after long term exposure to glucose using a Caenorhabditis elegans-E. coli system where only the bacteria have direct contact with glucose. Our data reveal that bacterial processing of glucose results in reduced lifespan and healthspan including reduced locomotion, oxidative stress resistance, and heat stress resistance in C. elegans. With chronic exposure to glucose, E. coli exhibits growth defects and increased advanced glycation end products. These negative effects are abrogated when the E. coli is not able to process the additional glucose and by the addition of the anti-glycation compound carnosine. Physiological changes of the host C. elegans are accompanied by dysregulation of detoxifying genes including glyoxalase, glutathione-S-transferase, and superoxide dismutase. Loss of the glutathione-S-transferase, gst-4 shortens C. elegans lifespan and blunts the animal's response to a glucose fed bacterial diet. Taken together, we reveal that added dietary sugar may alter intestinal microbial E. coli to decrease lifespan and healthspan of the host and define a critical role of detoxification genes in maintaining health during a chronic high-sugar diet. |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-021-85046-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07af6b3bec587c454c79cf8f20959e9a https://doi.org/10.1038/s41598-021-85046-3 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....07af6b3bec587c454c79cf8f20959e9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-85046-3 |