The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma
| العنوان: | The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma |
|---|---|
| المؤلفون: | Daniel Neureiter, Thomas Melchardt, Daniel Reitz, Katharina Troppan, Alexander Egle, Richard Greil, Kerstin Wenzl, Konstantin Schlick, Lukas Weiss, Martin Pichler, Marc D. Bullock, Wolfgang Tränkenschuh, Alexander Deutsch, Peter Neumeister, Christine Beham-Schmid |
| المصدر: | Journal of Clinical Pathology. 69:326-330 |
| بيانات النشر: | BMJ, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Pathology, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Fibrinogen, Disease-Free Survival, Pathology and Forensic Medicine, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Humans, Clinical significance, Aged, Proportional Hazards Models, Retrospective Studies, business.industry, Proportional hazards model, Cancer, General Medicine, Plasma levels, Middle Aged, Prognosis, medicine.disease, Pathophysiology, ROC Curve, Area Under Curve, 030220 oncology & carcinogenesis, Female, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma, medicine.drug |
| الوصف: | Fibrinogen plays a crucial role in the pathophysiology of tumour cell growth, invasion and metastasis. The aim of this study was to evaluate the prognostic significance of pretreatment plasma fibrinogen levels in patients with diffuse large B cell lymphoma (DLBCL) METHODS: Data from 372 patients with DLBCL, diagnosed and treated between 2004 and 2013 at two Austrian centres, were evaluated retrospectively. The prognostic influences of plasma fibrinogen levels and other factors, including age, tumour stage and the National Comprehensive Cancer Network-International Prognostic Index, on 5-year overall survival (OS) and 5-year disease-free survival (DFS) were studied using Kaplan-Meier curves as well as univariate and multivariate Cox regression models.Kaplan-Meier analysis revealed that a high fibrinogen plasma level is associated with decreased 5-year OS and 5-year DFS in patients with DLBCL (p0.001, log-rank test). Furthermore, in multivariate analysis, elevated serum fibrinogen was found to be an independent marker of poor clinical outcome: 5-year OS (HR=1.69, 95% CI 1.06 to 2.72, p=0.029) and 5-year DFS (HR=1.68, 95% CI 1.08 to 2.61, p=0.021).In the current study, we demonstrate that high plasma fibrinogen levels at diagnosis predict poor outcome in patients with DLBCL.25-434 ex 12713 and 415-EP/73/127-2012. |
| تدمد: | 1472-4146 0021-9746 |
| DOI: | 10.1136/jclinpath-2015-203356 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074fde51be443b5520af4dd0f2f019fb https://doi.org/10.1136/jclinpath-2015-203356 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....074fde51be443b5520af4dd0f2f019fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
|---|---|
| DOI: | 10.1136/jclinpath-2015-203356 |