Endothelial Effect of Statin Therapy at a High Dose Versus Low Dose Associated with Ezetimibe
| العنوان: | Endothelial Effect of Statin Therapy at a High Dose Versus Low Dose Associated with Ezetimibe |
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| المؤلفون: | Ana Marice Teixeira Ladeia, Patricia Fontes da Costa Silva, Carolina Garcez Varela, Maristela Magnavita Oliveira Garcia, Paulo Roberto Passos Lima, Luis C. L. Correia, Armênio Costa Guimarães, Paulo Meira Góes, Marília Galeffi Rodrigues, Maria de Lourdes Lima de Souza e Silva |
| المصدر: | Arquivos Brasileiros de Cardiologia Arquivos Brasileiros de Cardiologia v.106 n.4 2016 Sociedade Brasileira de Cardiologia (SBC) instacron:SBC Arquivos Brasileiros de Cardiologia, Vol 106, Iss 4, Pp 279-288 (2016) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, Simvastatin, Time Factors, Endothelium / physiology, Brachial Artery, Inibidores de Hidroximetil glutaril-CoA Redutases / uso terapêutico, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Reference Values, Hyperlipidemia, Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use, 030212 general & internal medicine, Anticholesteremic Agents, Middle Aged, Anticholesterolemic Agents, Vasodilation, medicine.anatomical_structure, Treatment Outcome, Cholesterol, lipids (amino acids, peptides, and proteins), Female, Original Article, Cardiology and Cardiovascular Medicine, Colesterol, medicine.drug, Adult, medicine.medical_specialty, Statin, Endothelium, medicine.drug_class, Urology, Hyperlipidemias, Placebo, Statistics, Nonparametric, 03 medical and health sciences, Ezetimibe, Double-Blind Method, medicine, Humans, cardiovascular diseases, Ezetimiba, Analysis of Variance, business.industry, Anticolesterolemiantes, nutritional and metabolic diseases, Cholesterol, LDL, medicine.disease, Placebo Effect, 030104 developmental biology, chemistry, lcsh:RC666-701, Endothelium, Vascular, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Endotélio / fisiologia |
| الوصف: | Background: The effect of statins on the endothelial function in humans remains under discussion. Particularly, it is still unclear if the improvement in endothelial function is due to a reduction in LDL-cholesterol or to an arterial pleiotropic effect. Objective: To test the hypothesis that modulation of the endothelial function promoted by statins is primarily mediated by the degree of reduction in LDL-cholesterol, independent of the dose of statin administered. Methods: Randomized clinical trial with two groups of lipid-lowering treatment (16 patients/each) and one placebo group (14 patients). The two active groups were designed to promote a similar degree of reduction in LDL-cholesterol: the first used statin at a high dose (80 mg, simvastatin 80 group) and the second used statin at a low dose (10 mg) associated with ezetimibe (10 mg, simvastatin 10/ezetimibe group) to optimize the hypolipidemic effect. The endothelial function was assessed by flow-mediated vasodilation (FMV) before and 8 weeks after treatment. Results: The decrease in LDL-cholesterol was similar between the groups simvastatin 80 and simvastatin 10/ezetimibe (27% ± 31% and 30% ± 29%, respectively, p = 0.75). The simvastatin 80 group presented an increase in FMV from 8.4% ± 4.3% at baseline to 11% ± 4.2% after 8 weeks (p = 0.02). Similarly, the group simvastatin 10/ezetimibe showed improvement in FMV from 7.3% ± 3.9% to 12% ± 4.4% (p = 0.001). The placebo group showed no variation in LDL-cholesterol level or endothelial function. Conclusion: The improvement in endothelial function with statin seems to depend more on a reduction in LDL-cholesterol levels, independent of the dose of statin administered, than on pleiotropic mechanisms. |
| وصف الملف: | text/html |
| تدمد: | 1678-4170 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e3a8b107dbfb67be0e524d38ead601 https://pubmed.ncbi.nlm.nih.gov/27142792 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....06e3a8b107dbfb67be0e524d38ead601 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16784170 |
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