Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis
| العنوان: | Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis |
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| المؤلفون: | Rainer Klocke, George Hirsch, Jacqueline P. Smith, Kirsty Levasseur, George D. Kitas |
| المصدر: | Klocke, R, Levasseur, K, Kitas, G, Smith, J P & Hirsch, G 2018, ' Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis ', Rheumatology International . https://doi.org/10.1007/s00296-018-3988-2 Rheumatology International |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cartilage, Articular, Male, Time Factors, Triamcinolone acetonide, Knee Joint, Osteoarthritis, Cartilage Oligomeric Matrix Protein, Severity of Illness Index, Triamcinolone Acetonide, Injections, Intra-Articular, 0302 clinical medicine, Adrenal Cortex Hormones, Immunology and Allergy, 030212 general & internal medicine, Anesthetics, Local, Hyaluronic Acid, Pain Measurement, Intra-articular corticosteroid, biology, Middle Aged, Osteoarthritis, Knee, Treatment Outcome, medicine.anatomical_structure, Female, Bone Remodeling, Knee osteoarthritis, medicine.symptom, Chondrogenesis, Procollagen, medicine.drug, musculoskeletal diseases, medicine.medical_specialty, WOMAC, Urine CTX-II, Immunology, Urology, Collagen Type I, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, Humans, Chitinase-3-Like Protein 1, Collagen Type II, Aged, 030203 arthritis & rheumatology, Cartilage oligomeric matrix protein, Bone and Cartilage, business.industry, Cartilage, Lidocaine, Biomarker, medicine.disease, Peptide Fragments, Knee pain, biology.protein, Peptides, business, Biomarkers |
| الوصف: | Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine. Knee pain (as pain subscale of WOMAC VAS) and biomarkers [C-telopeptides of type-II collagen (uCTX-II), and N-telopeptides of type-I collagen in urine; cartilage oligomeric matrix protein (COMP), hyaluronic acid, N-terminal propeptide of type-IIA collagen, and human cartilage glycoprotein-39 (YKL-40) in serum] were measured at baseline and 3 weeks after IACI. Radiographic severity of disease was evaluated using knee radiographs. Median uCTX-II, a cartilage degradation marker, was lower at 3 weeks post IACI compared with baseline: 306.3 and 349.9 ng/mmol, respectively (p |
| تدمد: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-018-3988-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066a488fa291a7e72623472bd8073f3b https://doi.org/10.1007/s00296-018-3988-2 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....066a488fa291a7e72623472bd8073f3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437160X 01728172 |
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| DOI: | 10.1007/s00296-018-3988-2 |