The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
| العنوان: | The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins |
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| المؤلفون: | Michael J. Sherratt, Sarah H. Cartmell, Ren Jie Tuieng, Cliona C. Kirwan |
| المصدر: | Cells Cells, Vol 10, Iss 3041, p 3041 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chronic exposure, skin, QH301-705.5, medicine.medical_treatment, Review, Electromagnetic radiation, Models, Biological, Ionizing radiation, Extracellular matrix, Dermis, Radiation, Ionizing, X-rays, medicine, Animals, Humans, Irradiation, Biology (General), breast, radiotherapy, Breast stroma, ultraviolet (UV) radiation, Extracellular Matrix Proteins, Chemistry, ionising radiation, Electromagnetic Radiation, General Medicine, extracellular matrix (ECM), Extracellular Matrix, Radiation therapy, medicine.anatomical_structure, Biophysics |
| الوصف: | Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whilst attention has focused primarily on the interaction of electromagnetic radiation with cells and cellular components, radiation-induced damage to long-lived extracellular matrix (ECM) proteins has the potential to profoundly affect tissue structure, composition and function. This review focuses on the current understanding of the biological effects of ionising and non-ionising radiation on the ECM of breast stroma and skin dermis, respectively. Although there is some experimental evidence for radiation-induced damage to ECM proteins, compared with the well-characterised impact of radiation exposure on cell biology, the structural, functional, and ultimately clinical consequences of ECM irradiation remain poorly defined. |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06505c74d803bfdb39faaeb525bbb9d1 https://pubmed.ncbi.nlm.nih.gov/34831262 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....06505c74d803bfdb39faaeb525bbb9d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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