Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer
| العنوان: | Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer |
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| المؤلفون: | Francesco Cavaliere, Virginia Fernández, Annalisa Massari, Marco Segatto, Marco Fiocchetti, Sabrina Ghinassi, Maria Marino, Manuela Cipolletti, Paolo Cercola |
| المساهمون: | Solar Fernandez, V., Fiocchetti, M., Cipolletti, M., Segatto, M., Cercola, P., Massari, A., Ghinassi, S., Cavaliere, F., Marino, M. |
| المصدر: | Cells Volume 10 Issue 8 Cells, Vol 10, Iss 1986, p 1986 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Estrogen receptor, 0302 clinical medicine, Ductal, 80 and over, Tumor Microenvironment, breast cancer survival, Breast, Biology (General), Aged, 80 and over, Tumor, Carcinoma, Ductal, Breast, General Medicine, Middle Aged, ductal infiltrating adenocarcinoma, Immunohistochemistry, Progression-Free Survival, Tumor microenvironment, 030220 oncology & carcinogenesis, Neuroglobin, Disease Progression, Female, Case-Control Studie, Breast Neoplasm, Breast cancer survival, Human, Signal Transduction, Adult, QH301-705.5, medicine.drug_class, Estrogen receptor α, Breast Neoplasms, Article, 03 medical and health sciences, Breast cancer, medicine, Biomarkers, Tumor, Humans, Globin, Protein kinase B, Aged, business.industry, AKT, Carcinoma, Estrogen Receptor alpha, estrogen receptor α, medicine.disease, 030104 developmental biology, Ductal infiltrating adenocarcinoma, Estrogen, Case-Control Studies, Cancer cell, Cancer research, Neoplasm Grading, Proto-Oncogene Proteins c-akt, business, Biomarkers |
| الوصف: | The expression of the α-subtype of Estrogen Receptor (ERα) characterizes most breast cancers (more than 75%), for which endocrine therapy is the mainstay for their treatment. However, a high percentage of ERα+ breast cancers are de novo or acquired resistance to endocrine therapy, and the definition of new targets for improving therapeutic interventions and the prediction of treatment response is demanding. Our previous data identified the ERα/AKT/neuroglobin (NGB) pathway as a common pro-survival process activated in different ERα breast cancer cell lines. However, no in vivo association between the globin and the malignity of breast cancer has yet been done. Here, we evaluated the levels and localization of NGB in ERα+ breast ductal carcinoma tissue of different grades derived from pre-and post-menopausal patients. The results indicate a strong association between NGB accumulation, ERα, AKT activation, and the G3 grade, while no association with the menopausal state has been evidenced. Analyses of the data set (e.g., GOBO) strengthen the idea that NGB accumulation could be linked to tumor cell aggressiveness (high grade) and resistance to treatment. These data support the view that NGB accumulation, mainly related to ER expression and tumor grade, represents a compensatory process, which allows cancer cells to survive in an unfavorable environment. |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bf8e04d46f075d50c5f617f9815df https://pubmed.ncbi.nlm.nih.gov/34440755 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....062bf8e04d46f075d50c5f617f9815df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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