Searching for a common origin of heat-transfer effects in bio- and chemosensors: A study on thiols as a model system
| العنوان: | Searching for a common origin of heat-transfer effects in bio- and chemosensors: A study on thiols as a model system |
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| المؤلفون: | Peter Cornelis, Patrick Wagner, Mehran Khorshid, Sven Ingebrandt, Bart van Grinsven, Christ Glorieux, Ronald Thoelen, Patricia Losada-Pérez, Frank Uwe Renner, Michèle Dollt, Ward De Ceuninck |
| المساهمون: | Sensor Engineering, RS: FSE Sensor Engineering |
| المصدر: | Sensors and actuators B Chemical, 310 Sensors and Actuators B-Chemical, 310:127627. Elsevier Science |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Phase transition, Work (thermodynamics), ADSORPTION, Thermal resistance, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Adsorption, LABEL-FREE DETECTION, Materials Chemistry, Molecule, Electrical and Electronic Engineering, Instrumentation, Self-assembling thiol monolayers, KINETICS, chemistry.chemical_classification, Chemistry, THERMAL TRANSPORT, Biomolecule, digestive, oral, and skin physiology, Metals and Alloys, DNA, Heat-transfer method (HTM), GOLD-SULFUR INTERFACE, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Thermal conduction, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, RESOLUTION, CONDUCTION, Chemical physics, PRINCIPLES, Molecular vibration, Quartz-crystal microbalance with dissipation monitoring (QCM-D), Thermal resistance at interfaces, 0210 nano-technology, RESISTANCE, Sciences exactes et naturelles |
| الوصف: | The heat-transfer method HTM is a bioanalytical technique in which a temperature gradient is established between the backside of a functionalized chip and the supernatant liquid. By combining the measured temperature difference with the power used to generate this gradient, one obtains the thermal resistance Rth. This parameter responds sensitively and in a concentration-dependent way to the binding of bioparticles to receptors as well as to phase transitions in coatings on the chip. The size of particles that can be detected with HTM spans from low-molecular weight molecules over proteins and DNA fragments up to cells with diameters at the micron scale. In this work, we explore the question whether and why small ligands adsorption can result still in quantifiable Rth changes and whether there is a common origin of the generally observed Rth increase upon binding a wide variety of cells and biomolecules. The data obtained on thiols with different capping groups suggest that the correspondence of molecular vibration frequencies of the ligands and the liquid is decisive for an efficient or impeded heat transfer and hence for the macroscopically determined Rth parameter. info:eu-repo/semantics/published |
| وصف الملف: | 2 full-text file(s): application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 0925-4005 |
| DOI: | 10.1016/j.snb.2019.127627 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058b02a210759d4f8d7f28e0403c2b68 https://doi.org/10.1016/j.snb.2019.127627 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....058b02a210759d4f8d7f28e0403c2b68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09254005 |
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| DOI: | 10.1016/j.snb.2019.127627 |