التفاصيل البيبلوغرافية
| العنوان: |
TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells |
| المؤلفون: |
Mason Bond, Guobin Sun, Cornelius F. Boerkoel, Kunho Choi, Timothy J. Triche, Cheryl Walton, Maureen J. O'Sullivan, Sheetal A. Mitra, Miraj K. Chowdhury, Nichola Osborne, Catherine J. Pallen, Hok Khim Fam, Gulisa Turashvili, Samuel Aparicio, Patrick Wong |
| المصدر: |
Molecular cancer research : MCR. 11(10) |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
musculoskeletal diseases, Serum, Cancer Research, DNA Repair, Myoblasts, Skeletal, Poly (ADP-Ribose) Polymerase-1, Antineoplastic Agents, Biology, Poly(ADP-ribose) Polymerase Inhibitors, urologic and male genital diseases, Poly (ADP-Ribose) Polymerase Inhibitor, Gene Knockout Techniques, PARP1, hemic and lymphatic diseases, Cell Line, Tumor, Rhabdomyosarcoma, medicine, Cytotoxic T cell, Humans, Cytotoxicity, Child, neoplasms, Molecular Biology, Survival rate, BRCA2 Protein, BRCA1 Protein, Phosphoric Diester Hydrolases, Soft tissue sarcoma, Gene Expression Profiling, Cancer, medicine.disease, female genital diseases and pregnancy complications, Glucose, Oncology, Tissue Array Analysis, Mutation, Cancer research, Camptothecin, Poly(ADP-ribose) Polymerases |
| الوصف: |
Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Metastatic rhabdomyosarcoma in children has a 5-year event-free survival rate of Implications: Selective targeting of TDP1 and/or PARP-1 in rhabdomyosarcoma induces cytotoxicity and sensitizes to DNA damaging agents. Mol Cancer Res; 11(10); 1179–92. ©2013 AACR. |
| تدمد: |
1557-3125 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f73401915e9526b56b5302f78d2598
https://pubmed.ncbi.nlm.nih.gov/23913164 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....04f73401915e9526b56b5302f78d2598 |
| قاعدة البيانات: |
OpenAIRE |