Involvement of 5‐HT‐BDNF signaling axis in mediating synergistic antidepressant‐like effects after combined administration of two oligosaccharide esters
| العنوان: | Involvement of 5‐HT‐BDNF signaling axis in mediating synergistic antidepressant‐like effects after combined administration of two oligosaccharide esters |
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| المؤلفون: | Zhen‐Guo Shi, Xian-Zhe Dong, Yuan Hu, Meng-li Chen, Wenshan Yang, Ping Liu |
| المصدر: | Food Science & Nutrition, Vol 9, Iss 2, Pp 1180-1191 (2021) Food Science & Nutrition |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Hippocampus, lcsh:TX341-641, herb activity compounds, Pharmacology, CREB, multi‐target, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neurotrophic factors, synergistic mechanism, Cyclic adenosine monophosphate, 5-HT receptor, Original Research, biology, Chemistry, Tail suspension test, 030104 developmental biology, BDNF, biology.protein, Antidepressant, lcsh:Nutrition. Foods and food supply, 030217 neurology & neurosurgery, Food Science, Behavioural despair test |
| الوصف: | Potential mechanisms of depression involving herbal medicines and their specific compounds include elevated 5‐HT level and downstream BDNF pathway. To identify potentially new combined therapeutic strategies, 3,6'‐disinapoylsucrose (DISS) and tenuifoliside A (TFSA) have been observed to show antidepressant‐like effects and its related 5‐HT‐BDNF pathway. We have tried to investigate whether combined administration of DISS and TFSA exerted more effective in the treatment of depression, as assessed through tail suspension test (TST) and forced swimming test (FST). In addition, we also analyzed the expression of three important proteins, cyclic adenosine monophosphate (cAMP) response element binding (CREB), brain‐derived neurotrophic factor (BDNF), and cAMP‐regulated transcriptional coactivators (CRTC1), which have been shown to be involved in the regulation of the neurotrophic factors in the hippocampus. The DISS and TFSA separately, both at a dose of 5 mg/kg each, displayed small effect in the immobility time. However, combined treatment of these two in multiple doses exhibited better effect. Moreover, combined treatment of DISS and TFSA also demonstrated enhanced levels of 5‐hydroxytryptamine (5‐HT), and stronger increase in the phosphorylation levels of CREB, BDNF, and CRTC1 proteins in the hippocampus. Overall, our results indicated that coadministration of these two oligosaccharide esters at low dose may induce more pronounced antidepressant activity, in comparison with individual treatment even at high dosage. Thus, the antidepressant properties of both these compounds can be attributed to their ability to influence 5‐HT and BDNF pathway, and thereby suggesting that this combination strategy can definitely act as alternative therapy for depression disorder with very limited side effects. The antidepressant properties of DISS and TFSA can be attributed to their ability to influence 5‐HT and BDNF pathway, and thereby suggesting that this combination strategy can definitely act as alternative therapy for depression disorder with very limited side effects. |
| اللغة: | English |
| تدمد: | 2048-7177 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044785b561c2e477e0ee77cbfee8f71e https://doaj.org/article/35f28277800249128238b6fe9cf58092 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....044785b561c2e477e0ee77cbfee8f71e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20487177 |
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