التفاصيل البيبلوغرافية
| العنوان: |
Right- and left-sided colorectal cancers respond differently to cetuximab |
| المؤلفون: |
Miao Zhen Qiu, Hui Yan Luo, Kai Yan Liu, Yi Yi Yu, Ming Ming He, Y. Jin, Yu Hong Li, Zhi Qiang Wang, T. Liu, De Shen Wang, Feng Wang, Chao Ren, Feng Hua Wang, Long Bai, Dong Sheng Zhang, Rui-Hua Xu |
| المصدر: |
Chinese Journal of Cancer |
| بيانات النشر: |
Springer Nature |
| مصطلحات موضوعية: |
Oncology, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Cetuximab, Treatment results, Left sided, Disease-Free Survival, Right-sided, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Humans, Medicine, In patient, Retrospective Studies, business.industry, Retrospective cohort study, medicine.disease, Primary tumor, digestive system diseases, Left-sided, Colonic Neoplasms, Original Article, Colorectal Neoplasms, business, medicine.drug |
| الوصف: |
Introduction Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated with the response to cetuximab in patients with metastatic colorectal cancer (mCRC). Methods Patients with mCRC treated with cetuximab and standard chemotherapy as first- or second-line treatments were compared with randomly chosen patients who were treated with chemotherapy alone between 2005 and 2013. The main outcome measures were the overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). The differences in the outcome were analyzed by using the chi-squared test, Student’s t test, and Kaplan-Meier method. Results The treatment results of 206 patients with mCRC treated with cetuximab and standard chemotherapy as first- or second-line treatments were compared with those of 210 patients who were treated with chemotherapy alone. As a first-line treatment, cetuximab with chemotherapy was associated with a significantly higher ORR (49.4 % vs. 28.6 %, P = 0.005) as well as longer PFS (9.1 vs. 6.2 months, P = 0.002) and OS (28.9 vs. 20.1 months, P = 0.036) than chemotherapy alone in patients with LSCRC. However, cetuximab neither improved the ORR (36.4 % vs. 26.2 %, P = 0.349) nor prolonged PFS (5.6 vs. 5.7 months, P = 0.904) or OS (25.1 vs. 19.8 months, P = 0.553) in patients with RSCC. As a second-line treatment, cetuximab exhibited a tendency to improve the ORR (23.5 % vs. 10.2 %, P = 0.087) and prolong PFS (4.9 vs. 3.5 months, P = 0.064), and it significantly prolonged OS (17.1 vs. 12.4 months, P = 0.047) compared with chemotherapy alone in the patients with LSCRC. In contrast, as a second-line treatment, cetuximab neither improved the ORR (7.1 % vs. 11.4 %, P = 0.698) nor prolonged PFS (3.3 vs. 4.2 months, P = 0.761) or OS (13.4 vs. 13.0 months, P = 0.652) in patients with RSCC. Conclusions The addition of cetuximab to chemotherapy in both first- and second-line treatments of mCRC may only benefit patients with primary LSCRC. |
| اللغة: |
English |
| تدمد: |
1944-446X |
| DOI: |
10.1186/s40880-015-0022-x |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03de9d5893022b3a336726c2f8397fde |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....03de9d5893022b3a336726c2f8397fde |
| قاعدة البيانات: |
OpenAIRE |