Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites
| العنوان: | Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites |
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| المؤلفون: | Antoine Daunay, Lise M. Hardy, Yosra Bouyacoub, Mourad Sahbatou, Mathilde Touvier, Hélène Blanché, Jean-François Deleuze, Alexandre How-Kit |
| المساهمون: | Fondation Jean Dausset CEPH, Laboratory of Excellence GENMED [Paris] (Medical Genomics), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de Recherche en Génomique Humaine (CNRGH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Bertram, Marie-Liesse |
| المصدر: | Aging Aging, 2022, 14 (19), pp.7718-7733. ⟨10.18632/aging.204316⟩ |
| بيانات النشر: | Impact Journals, LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aged, 80 and over, Epigenomics, Aging, [SDV]Life Sciences [q-bio], Cell Biology, DNA Methylation, Epigenesis, Genetic, [SDV] Life Sciences [q-bio], pyrosequencing, longevity, Centenarians, Humans, CpG Islands, DNAmage, epigenetic clock |
| الوصف: | International audience; Aging is a progressive time-dependent biological process affecting differentially individuals, who can sometimes present exceptional longevity. Epigenetic alterations are one of the hallmarks of aging, which comprise the epigenetic drift and clock at DNA methylation level. In the present study, we estimated the DNA methylation-based age (DNAmage) using four epigenetic clocks based on a small number of CpGs in French centenarians and semi-supercentenarians (CSSC, n=214) as well as nonagenarians' and centenarians' offspring (NCO, n=143) compared to individuals from the French general population (CG, n=149). DNA methylation analysis of the nine CpGs included in the epigenetic clocks showed high correlation with chronological age (-0.66>R>0.54) and also the presence of an epigenetic drift for four CpGs that was only visible in CSSC. DNAmage analysis showed that CSSC and to a lesser extend NCO present a younger DNAmage than their chronological age (15-28.5 years for CSSC, 4.4-11.5 years for NCO and 4.2-8.2 years for CG), which were strongly significant in CSSC compared to CG (p-values |
| وصف الملف: | application/pdf |
| تدمد: | 1945-4589 |
| DOI: | 10.18632/aging.204316 |
| DOI: | 10.18632/aging.204316⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b59f7604cc424db2431fb6da6111f5 https://doi.org/10.18632/aging.204316 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03b59f7604cc424db2431fb6da6111f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19454589 |
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| DOI: | 10.18632/aging.204316 |