Annexin A2 is required for the early steps of cytokinesis
| العنوان: | Annexin A2 is required for the early steps of cytokinesis |
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| المؤلفون: | Claude Prigent, Svetlana Mironov, Christelle Benaud, Gaëlle Le Dez, Federico Galli, David Reboutier |
| المساهمون: | Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| المصدر: | EMBO Reports EMBO Reports, EMBO Press, 2015, 16 (4), pp.481-9. ⟨10.15252/embr.201440015⟩ EMBO Reports, 2015, 16 (4), pp.481-9. ⟨10.15252/embr.201440015⟩ |
| بيانات النشر: | EMBO, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], Green Fluorescent Proteins, Spindle Apparatus, Chromatids, Biochemistry, Genes, Reporter, Cell Line, Tumor, Proto-Oncogene Proteins, Genetics, Humans, Point Mutation, Cleavage furrow, RNA, Small Interfering, Central spindle, Cytoskeleton, Molecular Biology, Mitosis, ComputingMilieux_MISCELLANEOUS, Annexin A2, Cytokinesis, mitosis, Binding Sites, Osteoblasts, Chemistry, S100 Proteins, Scientific Reports, Actin remodeling, RhoA, Recombinant Proteins, Cell biology, Spindle apparatus, Luminescent Proteins, Gene Expression Regulation, rhoA GTP-Binding Protein, HeLa Cells, Protein Binding, Signal Transduction |
| الوصف: | Cytokinesis requires the formation of an actomyosin contractile ring between the two sets of sister chromatids. Annexin A2 is a calcium- and phospholipid-binding protein implicated in cortical actin remodeling. We report that annexin A2 accumulates at the equatorial cortex at the onset of cytokinesis and depletion of annexin A2 results in cytokinetic failure, due to a defective cleavage furrow assembly. In the absence of annexin A2, the small GTPase RhoA—which regulates cortical cytoskeletal rearrangement—fails to form a compact ring at the equatorial plane. Furthermore, annexin A2 is required for cortical localization of the RhoGEF Ect2 and to maintain the association between the equatorial cortex and the central spindle. Our results demonstrate that annexin A2 is necessary in the early phase of cytokinesis. We propose that annexin A2 participates in central spindle–equatorial plasma membrane communication. |
| تدمد: | 1469-3178 1469-221X |
| DOI: | 10.15252/embr.201440015 |
| DOI: | 10.15252/embr.201440015⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9e31f7ffecd1fb1d21d1785985e82 https://doi.org/10.15252/embr.201440015 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03a9e31f7ffecd1fb1d21d1785985e82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14693178 1469221X |
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| DOI: | 10.15252/embr.201440015 |