Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs
| العنوان: | Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs |
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| المؤلفون: | Sylvain D. Vallet, Sylvie Ricard-Blum |
| المساهمون: | Assemblages Supramoléculaires Péricellulaires et Extracellulaires (ASPE), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Microbiologie moléculaire et biochimie structurale / Molecular Microbiology and Structural Biochemistry (MMSB), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Matrix Biology Matrix Biology, Elsevier, 2019, 75-76, pp.170-189. ⟨10.1016/j.matbio.2017.11.005⟩ |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Proteases, Angiogenesis, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Autophagy, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Neoplasm Metastasis, Receptor, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Wound Healing, Adipogenesis, Neovascularization, Pathologic, Chemistry, Translation (biology), Models, Theoretical, Fibrosis, Extracellular Matrix, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Wound healing, Peptide Hydrolases |
| الوصف: | The remodeling of the extracellular matrix (ECM) by several protease families releases a number of bioactive fragments, which regulate numerous biological processes such as autophagy, angiogenesis, adipogenesis, fibrosis, tumor growth, metastasis and wound healing. We review here the proteases which generate bioactive ECM fragments, their ECM substrates, the major bioactive ECM fragments, together with their biological properties and their receptors. The translation of ECM fragments into drugs is challenging and would take advantage of an integrative approach to optimize the design of pre-clinical and clinical studies. This could be done by building the contextualized interaction network of the ECM fragment repertoire including their parent proteins, remodeling proteinases, and their receptors, and by using mathematical disease models. |
| تدمد: | 0945-053X |
| DOI: | 10.1016/j.matbio.2017.11.005 |
| DOI: | 10.1016/j.matbio.2017.11.005⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0337567a168a22b915dda3cc70a31a94 https://doi.org/10.1016/j.matbio.2017.11.005 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0337567a168a22b915dda3cc70a31a94 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0945053X |
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| DOI: | 10.1016/j.matbio.2017.11.005 |