Epileptiform activity and seizures in patients with COVID-19
| العنوان: | Epileptiform activity and seizures in patients with COVID-19 |
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| المؤلفون: | Jared Davis, Richard Wlodarski, Shasha Wu, Fabiane Santos de Lima, James X. Tao, Naoum P. Issa, Sandra Rose, Peter C. Warnke, Kaitlin Seibert, Sara Klein, Faten El Ammar |
| المصدر: | Journal of Neurology, Neurosurgery & Psychiatry |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Clinical Neurology, Sepsis, Young Adult, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Risk Factors, Seizures, Internal medicine, Prevalence, Humans, Medicine, Medical history, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Organ dysfunction, COVID-19, Electroencephalography, Retrospective cohort study, Symptomatic seizures, Pneumonia, Middle Aged, medicine.disease, Psychiatry and Mental health, Viral pneumonia, Anticonvulsants, Female, Surgery, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Acute symptomatic seizures have been reported in sporadic cases in patients with COVID-19.1 2 However, a recent large retrospective cohort study suggested that there was no increased risk of acute symptomatic seizures in these patients.3 As such, the association of seizures with COVID-19 has not been established. Admittedly, EEG studies have been significantly underused due to exposure concerns, and epileptiform activity has seldom been identified in this patient population. The aims of this study were to determine the prevalence of epileptiform activity and to assess the risk of seizures in patients with COVID-19. We retrospectively reviewed consecutive patients with COVID-19 from 1 March to 27 May 2020 in a single institution. Patients were included if they were (1) ≥18 years of age, (2) positive for nasal swab SARS-CoV-2 RNA qualitative PCR test and (3) underwent EEG monitoring. Patients with a prior active diagnosis of epilepsy were excluded. Patient data regarding demographics, medical history, neuroimaging, laboratory tests, complications, mortality, metabolic profiles and treatment were extracted from electronic medical records. COVID-19 disease severity was categorised according to WHO guideline into (1) non-severe: absence of viral pneumonia or hypoxia, or clinical signs of pneumonia but SpO2 of >90% on room air; (2) severe: clinical pneumonia, respiratory rate of >30 and SpO2 of |
| تدمد: | 1468-330X 0022-3050 |
| DOI: | 10.1136/jnnp-2020-324337 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03039a83c9fcabe3091700fded826c85 https://doi.org/10.1136/jnnp-2020-324337 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03039a83c9fcabe3091700fded826c85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468330X 00223050 |
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| DOI: | 10.1136/jnnp-2020-324337 |