Correlation and association between plasma platelet-, monocyte- and endothelial cell-derived microparticles in hypertensive patients with type 2 diabetes mellitus
| العنوان: | Correlation and association between plasma platelet-, monocyte- and endothelial cell-derived microparticles in hypertensive patients with type 2 diabetes mellitus |
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| المؤلفون: | Shosaku Nomura, Fumiaki Urase, Akira Shouzu, Norihito Inami, Yasuhiro Maeda |
| المصدر: | Platelets. 20:406-414 |
| بيانات النشر: | Informa UK Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Blood Pressure, Type 2 diabetes, chemistry.chemical_compound, High-density lipoprotein, Cell-Derived Microparticles, Internal medicine, Diabetes mellitus, Blood plasma, medicine, Humans, Platelet, Platelet activation, Cholesterol, business.industry, Type 2 Diabetes Mellitus, Hematology, General Medicine, Middle Aged, Flow Cytometry, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Hypertension, Female, Chemokines, business, Biomarkers |
| الوصف: | Elevated platelet-derived mircoparticles (MP) (PDMP), endothelial cell-derived MP (EDMP), and monocyte-derived MP (MDMP) concentrations are documented in almost all thrombotic diseases. However, the intricate interactions between PDMP, MDMP and EDMP in hypertensive patients with or without type 2 diabetes remains poorly understood. Therefore, to clarify the correlation and association of MPs, we measured and analysed the levels of MPs in 359 hypertensive patients. We compared the results of chemokines, cell adhesion molecules, platelet activation markers and microparticles in hypertensive patients with and without type 2 diabetes mellitus. The levels of all markers were significantly higher in the hypertensive patients with diabetes than in the non-diabetic patients. For hypertensive patients with diabetes, univariate analysis showed that age, body mass index, systolic blood pressure, high density lipoprotein cholesterol (HDL-CHO), creatinine (CRTN), soluble P-selectin (sP-selectin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble CD40 ligand (sCD40L), regulated on activation normally T-cell expressed and secreted (RANTES), monocyte chemotactic peptide-1 (MCP-1), MDMP and EDMP were significantly associated with PDMP. In addition, systolic blood pressure, HDL cholesterol, sP-selectin, sE-selectin, sVCAM-1, sCD40L, RANTES, MDMP and EDMP were significant factors in the multivariate model with PDMP. Furthermore, a correlation between plasma PDMP and MDMP or EDMP in hypertensive patients were observed both with and without diabetes. These results suggest that the existence of diabetes mellitus affects PDMP generation in hypertensive patients and that enhanced plasma levels of PDMP and an association between the plasma levels of PDMP, MDMP and EDMP may result in the development of atherothrombotic complications in hypertensive patients. |
| تدمد: | 1369-1635 0953-7104 |
| DOI: | 10.1080/09537100903114545 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e5c7f85818e8aa69b049958c7d4844 https://doi.org/10.1080/09537100903114545 |
| رقم الانضمام: | edsair.doi.dedup.....02e5c7f85818e8aa69b049958c7d4844 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13691635 09537104 |
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| DOI: | 10.1080/09537100903114545 |