Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-κB in a mouse model of TBI
| العنوان: | Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-κB in a mouse model of TBI |
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| المؤلفون: | Shuyu Hao, Zonggang Hou, Xiaogang Tao, Xuetao Chen, Xiang Mao, Ming Sun, Baiyun Liu, Runfa Tian, Zhendan Zhu |
| المصدر: | Brain Injury. :1-11 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, Traumatic brain injury, Poly ADP ribose polymerase, Neuroscience (miscellaneous), Inflammation, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Developmental and Educational Psychology, Medicine, biology, business.industry, NF-κB, Calpain, medicine.disease, 030104 developmental biology, chemistry, Apoptosis, Immunology, PARP inhibitor, biology.protein, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Poly(ADP-ribose) polymerase (PARP), calpain and nuclear factor-κB (NF-κB) are reported to participate in inflammatory reactions in pathological conditions and are involved in traumatic brain injury. The objective of this study was to investigate whether PARP participated in inflammation related to calpain and NF-κB in a mouse model of controlled cortical impact (CCI).PJ34 (10 mg kgTreatment with PJ34 markedly reduced neurological deficits, decreased contusion volume and attenuated necrotic and apoptotic neuronal cell death 24 hours after CCI. The data showed that the cytosolic and nuclear fractions of calpain and NF-κB were up-regulated in the injured cortex and that these changes were reversed by PJ34. Moreover, PJ34 significantly enhanced the calpastatin and IκB levels and decreased the levels of inflammatory mediators.PARP inhibition by PJ34 suppresses the over-activation of calpain and the production of inflammatory factors that are caused by NF-κB activation and it improves neurological functioning, decreases the contusion volume and attenuates neuronal cell death in a mouse model of CCI. |
| تدمد: | 1362-301X 0269-9052 |
| DOI: | 10.3109/02699052.2016.1160151 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029e33aff536654e253c21ed5b4b0694 https://doi.org/10.3109/02699052.2016.1160151 |
| رقم الانضمام: | edsair.doi.dedup.....029e33aff536654e253c21ed5b4b0694 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1362301X 02699052 |
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| DOI: | 10.3109/02699052.2016.1160151 |