One-year clinical outcomes following theta burst stimulation for post-traumatic stress disorder
| العنوان: | One-year clinical outcomes following theta burst stimulation for post-traumatic stress disorder |
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| المؤلفون: | Jennifer Barredo, Amin Zandvakili, Noah S. Philip, Emily Aiken, Nicholas J Petrosino, Hannah R. Swearingen, Mascha van 't Wout-Frank |
| المصدر: | Neuropsychopharmacology |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Stimulation, Article, Stress Disorders, Post-Traumatic, Neuroimaging, Internal medicine, Humans, Medicine, Theta Rhythm, Adverse effect, Default mode network, Veterans, Pharmacology, Cross-Over Studies, business.industry, Traumatic stress, Middle Aged, Transcranial Magnetic Stimulation, Crossover study, Theta burst, Transcranial magnetic stimulation, Psychiatry and Mental health, Outcomes research, Female, business, Biomarkers |
| الوصف: | Theta burst transcranial magnetic stimulation (TBS) is a potential new treatment for post-traumatic stress disorder (PTSD). We previously reported active intermittent TBS (iTBS) was associated with superior clinical outcomes for up to 1-month, in a sample of fifty veterans with PTSD, using a crossover design. In that study, participants randomized to the active group received a total of 4-weeks of active iTBS, or 2-weeks if randomized to sham. Results were superior with greater exposure to active iTBS, which raised the question of whether observed effects persisted over the longer-term. This study reviewed naturalistic outcomes up to 1-year from study endpoint, to test the hypothesis that greater exposure to active iTBS would be associated with superior outcomes. The primary outcome measure was clinical relapse, defined as any serious adverse event (e.g., suicide, psychiatric hospitalization, etc.,) or need for retreatment with repetitive transcranial magnetic stimulation (rTMS). Forty-six (92%) of the initial study’s intent-to-treat participants were included. Mean age was 51.0 ± 12.3 years and seven (15.2%) were female. The group originally randomized to active iTBS (4-weeks active iTBS) demonstrated superior outcomes at one year compared to those originally randomized to sham (2-weeks active iTBS); log-rank ChiSq = 5.871, df = 1, p = 0.015; OR = 3.50, 95% CI = 1.04–11.79. Mean days to relapse were 296.0 ± 22.1 in the 4-week group, and 182.0 ± 31.9 in the 2-week group. When used, rTMS retreatment was generally effective. Exploratory neuroimaging revealed default mode network connectivity was predictive of 1-year outcomes (corrected p |
| تدمد: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-019-0584-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0286c6d6b155663b7eca94c5a120d2c8 https://doi.org/10.1038/s41386-019-0584-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0286c6d6b155663b7eca94c5a120d2c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1740634X 0893133X |
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| DOI: | 10.1038/s41386-019-0584-4 |