Thresholds in genotoxicity responses

التفاصيل البيبلوغرافية
العنوان: Thresholds in genotoxicity responses
المؤلفون: Leigh Henderson, Marilyn J. Aardema, Silvio Albertini
المصدر: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 464:123-128
بيانات النشر: Elsevier BV, 2000.
سنة النشر: 2000
مصطلحات موضوعية: Genetics, Dose-Response Relationship, Drug, Cell division, Mutagenicity Tests, Health, Toxicology and Mutagenesis, Defence mechanisms, Mutagenesis (molecular biology technique), Mutagen, Pharmacology, Biology, medicine.disease_cause, Risk Assessment, United States, Europe, In vivo, Surveys and Questionnaires, Toxicity, medicine, Animals, Humans, Laboratories, Cytotoxicity, Genotoxicity, Mutagens
الوصف: It has been commonly accepted that risk assessments of genotoxic chemicals are based on linear extrapolation methods. However, there is substantial evidence that some chemicals may be genotoxic only at high doses by mechanisms that do not occur at low doses, or only under specific conditions in genotoxicity assays, but are inactive at concentrations within the range of human exposure levels. There are a variety of possible mechanisms of thresholded genotoxicity, including disruption of cell division and chromosome segregation, inhibition of DNA synthesis, overloading of oxidative defence mechanisms, metabolism or plasma binding capacity, disturbances of metal homeostasis, cytotoxicity and physiological perturbations in in vivo assays. The degrees of evidence supporting the proposed mechanisms are variable and not all are sufficiently robust to be universally accepted as yet by the scientific community. However, a survey of industrial companies indicated that data have been accepted by some regulatory authorities indicating thresholds contributing to genotoxicity responses.
تدمد: 1383-5718
DOI: 10.1016/s1383-5718(99)00173-4
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02852d56cdbdb66d833c484a742c47ed
https://doi.org/10.1016/s1383-5718(99)00173-4
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....02852d56cdbdb66d833c484a742c47ed
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13835718
DOI:10.1016/s1383-5718(99)00173-4