Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia
| العنوان: | Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia |
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| المؤلفون: | Ayhan Ulubelen, John M. Pezzuto, Heebyung Chai, Gulacti Topcu |
| المصدر: | Pharmaceutical Biology. 37:148-151 |
| بيانات النشر: | Informa UK Limited, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, biology, Traditional medicine, Salvia hypargeia, Pharmaceutical Science, Cancer, General Medicine, Salvia, Pharmacognosy, biology.organism_classification, medicine.disease, Ferruginol, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Triterpene, Drug Discovery, LNCaP, medicine, Molecular Medicine, Lupeol |
| الوصف: | Ten diterpenoids [6a-hydroxysalvinolone (1), 6 alpha-hydroxytaxodone (2), aethiopinone (3), microstegiol (4). ferruginol (5), saprorthoquinone (6, 11,12-dioxoabieta-8,13-diene (7), taxodione (8), hypargenin A (9), hypargenin D (10)] and three triterpenoids [lupeol 3-acetate, delta-oleanol 3-acetate and beta-sitosterol] were isolated from the roots of Salvia hypargeia, a plant Endemic to Turkey. The crude extract and compounds 1-2, 5-10 were tested against a panel of human cancer cell lines [human breast cancer (BC 1), human lung cancer (LU 2), human colon cancer (COL 2), human epidermoidal carcinoma in mouth (KB), vinblastine-resistant ICB-VI, hormone-dependent human prostate cancer (LNCaP)] as well as P388 and ASK cells in culture. The crude extract was active in all of the rest systems, except KB. Isolates 1 and 8 were also found to mediate a generalized cytotoxic response. |
| تدمد: | 1744-5116 1388-0209 |
| DOI: | 10.1076/phbi.37.2.148.6082 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0221a968ae77ad188377dcac7c3105af https://doi.org/10.1076/phbi.37.2.148.6082 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0221a968ae77ad188377dcac7c3105af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17445116 13880209 |
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| DOI: | 10.1076/phbi.37.2.148.6082 |