Plasma sCD14 Is a Biomarker Associated With Impaired Neurocognitive Test Performance in Attention and Learning Domains in HIV Infection
| العنوان: | Plasma sCD14 Is a Biomarker Associated With Impaired Neurocognitive Test Performance in Attention and Learning Domains in HIV Infection |
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| المؤلفون: | Elyse J. Singer, David Moore, Jennifer L. Lyons, Dana Gabuzda, Susan Morgello, Hajime Uno, Anupa Kamat, Petronela Ancuta |
| المصدر: | Journal of acquired immune deficiency syndromes (1999), vol 57, iss 5 Lyons, JL; Uno, H; Ancuta, P; Kamat, A; Moore, DJ; Singer, EJ; et al.(2011). Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection. Journal of Acquired Immune Deficiency Syndromes, 57(5), 371-379. doi: 10.1097/QAI.0b013e3182237e54. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9s70k7fc |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, AIDS Dementia Complex, Lipopolysaccharide Receptors, Neuropsychological Tests, medicine.disease_cause, Cohort Studies, HIV-associated neurocognitive disorders, Risk Factors, 2.1 Biological and endogenous factors, Attention, Pharmacology (medical), Aetiology, drug abuse, Hepatitis C, Middle Aged, AIDS, Mental Health, Infectious Diseases, HCV, Public Health and Health Services, Coinfection, HIV/AIDS, Biomarker (medicine), Female, Infection, Viral load, Adult, Cart, Hepatitis C virus, Clinical Sciences, Article, Clinical Research, Virology, Behavioral and Social Science, Acquired Cognitive Impairment, medicine, Humans, Learning, Aged, Receiver operating characteristic, business.industry, Neurosciences, HIV, biomarkers, Opioid-Related Disorders, medicine.disease, CD4 Lymphocyte Count, Brain Disorders, Good Health and Well Being, Immunology, business, Neurocognitive, Biomarkers |
| الوصف: | Author(s): Lyons, Jennifer L; Uno, Hajime; Ancuta, Petronela; Kamat, Anupa; Moore, David J; Singer, Elyse J; Morgello, Susan; Gabuzda, Dana | Abstract: ObjectiveMild forms of HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of combination antiretroviral therapy (cART). Although elevated lipopolysaccharide (LPS) and immune activation are implicated in HAND pathogenesis, relationships of LPS and inflammatory markers to mild forms of HAND or impairment in specific cognitive domains are unknown. To examine these relationships, we compared plasma soluble CD14 (sCD14), CCL2, and LPS levels with neurocognitive test scores in a cART era cohort.MethodsWe analyzed plasma from HIV+ subjects (n = 97) with nadir CD4 counts l300 and high frequency of hepatitis C virus coinfection and illicit drug use for relationships between sCD14, CCL2, and LPS levels and neurocognitive test scores.ResultsPlasma sCD14 levels were higher in subjects with test scores indicating global impairment (P = 0.007), particularly in attention and learning domains (P = 0.015 and P = 0.03, respectively), regardless of HAND diagnosis. Plasma sCD14 levels correlated inversely with global, attention, and learning T scores (P = 0.036, 0.047, and 0.007, respectively) and yielded higher area under receiver operating characteristic values for predicting impaired scores than single-marker models based on plasma or cerebrospinal fluid viral load or CD4 count (area under receiver operating characteristic values = 0.71, 0.81, and 0.71, respectively) and in 4-marker models based on plasma sCD14 and 3 conventional markers compared with the 3-marker models.ConclusionsPlasma sCD14 is a biomarker associated with impaired neurocognitive testing in attention and learning domains in HIV-infected individuals with advanced disease, suggesting involvement of cortical and limbic pathways by inflammatory processes in the cART era. Plasma sCD14 is a potential biomarker to monitor HAND progression and therapeutic responses. |
| وصف الملف: | application/pdf |
| تدمد: | 1525-4135 |
| DOI: | 10.1097/qai.0b013e3182237e54 |
| DOI: | 10.1097/QAI.0b013e3182237e54. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f3b610de7e557f4322070d1cf4251f https://doi.org/10.1097/qai.0b013e3182237e54 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....01f3b610de7e557f4322070d1cf4251f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15254135 |
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| DOI: | 10.1097/qai.0b013e3182237e54 |