Differential Transmission and Postnatal Outcomes in Triplets with Intrauterine Cytomegalovirus Infection
| العنوان: | Differential Transmission and Postnatal Outcomes in Triplets with Intrauterine Cytomegalovirus Infection |
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| المؤلفون: | Masayuki Ochiai, Hirosuke Inoue, Takahisa Yoshida, Shouichi Ohga, Tadamune Kinjo, Toshiro Hara, Koichi Kusuhara, Junko Kitajima |
| المصدر: | Pediatric and Developmental Pathology. 15:151-155 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Ganciclovir, Pathology, medicine.medical_specialty, Placenta, Congenital cytomegalovirus infection, Biology, Asymptomatic, Pathology and Forensic Medicine, Pregnancy, medicine, Humans, Autistic Disorder, Pregnancy Complications, Infectious, reproductive and urinary physiology, Differential transmission, Triplets, Amnion, Decidua, General Medicine, Pregnancy, Triplet, medicine.disease, Infectious Disease Transmission, Vertical, medicine.anatomical_structure, Cytomegalovirus Infections, embryonic structures, Pediatrics, Perinatology and Child Health, Immunology, Female, medicine.symptom, Viral load, medicine.drug |
| الوصف: | We present a case of triplets with intrauterine cytomegalovirus (CMV) infection, each of whom showed differential transmission, placental pathology, and postnatal outcome. The first- and second-born infants were both vigorous and asymptomatic at birth, although the first-, but not the second-born, triplet had a high copy number of CMV DNA in the peripheral blood (1.2 × 103 copy/mL). The third-born triplet suffered from symptomatic CMV infection with a high viral load (6.0 × 106 copy/mL). The triamniotic-trichorionic placentas were not fused to each other. The histopathologic analysis showed that CMV-positive cells were frequently found in the decidua, villi, and amnion of the third-born triplet's placenta but were limited and scattered in the decidua or villi but not amnion of the other 2 placentas. The third-born triplet underwent ganciclovir therapy. None of the infants had physical or auditory problems at 4 years of age, whereas the third-born triplet had been diagnosed with an autistic disorder. This observation exemplifies the preventive roles of the individual placentas of triplets with regard to virus infection, thus suggesting that developing CMV disease largely depends on the placental function. |
| تدمد: | 1615-5742 1093-5266 |
| DOI: | 10.2350/11-05-1034-cr.1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e07ccd26635e7f884bc0212ebe6b6c https://doi.org/10.2350/11-05-1034-cr.1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....00e07ccd26635e7f884bc0212ebe6b6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16155742 10935266 |
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| DOI: | 10.2350/11-05-1034-cr.1 |