Coenzyme Q
| العنوان: | Coenzyme Q |
|---|---|
| المؤلفون: | Jose Lopez-Miranda, Silvia de la Cruz-Ares, Jose D Torres-Peña, Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, Juan F. Alcala-Diaz |
| المصدر: | Antioxidants 10(6), 906 (2021) Antioxidants Helvia. Repositorio Institucional de la Universidad de Córdoba instname Helvia: Repositorio Institucional de la Universidad de Córdoba Universidad de Córdoba Antioxidants, Vol 10, Iss 906, p 906 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Ubiquinol, Antioxidant, Physiology, Ubiquinone, medicine.medical_treatment, Clinical Biochemistry, Context (language use), RM1-950, Review, 030204 cardiovascular system & hematology, Pharmacology, Mitochondrion, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, coenzyme Q10, ubiquinone, Medicine, Molecular Biology, Coenzyme Q10, business.industry, food and beverages, ubiquinol, Cell Biology, cardiovascular diseases, Clinical trial, Blood pressure, Cardiovascular diseases, chemistry, Therapeutics. Pharmacology, business, 030217 neurology & neurosurgery, Lipoprotein |
| الوصف: | Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins. CoQ10 deficiency is present in chronic and age-related diseases. In particular, in cardiovascular diseases (CVDs), there is a reduced bioavailability of CoQ10 since statins, one of the most common lipid-lowering drugs, inhibit the common pathway shared by CoQ10 endogenous biosynthesis and cholesterol biosynthesis. Different clinical trials have analyzed the effect of CoQ10 supplementation as a treatment to ameliorate these deficiencies in the context of CVDs. In this review, we focus on recent advances in CoQ10 supplementation and the clinical implications in the reduction of cardiovascular risk factors (such as lipid and lipoprotein levels, blood pressure, or endothelial function) as well as in a therapeutic approach for the reduction of the clinical complications of CVD. |
| وصف الملف: | application/pdf |
| تدمد: | 2076-3921 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00be10d779717546bbd33063d1a3cea6 https://pubmed.ncbi.nlm.nih.gov/34205085 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....00be10d779717546bbd33063d1a3cea6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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