Potato (Solanum tuberosum) Juice Exerts an Anticonvulsant Effect in Mice through Binding to GABA Receptors
| العنوان: | Potato (Solanum tuberosum) Juice Exerts an Anticonvulsant Effect in Mice through Binding to GABA Receptors |
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| المؤلفون: | Zane Dzirkale, Ruta Muceniece, Jorens Kviesis, Maija Dambrova, Rudolfs Mezhapuke, Helgi B. Schiöth, Peteris Mekss, Liga Krigere, Juris Rumaks, Vija Klusa, Kristine Saleniece |
| المصدر: | Planta Medica. 74:491-496 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, Pharmaceutical Science, Pharmacology, Pharmacognosy, Bicuculline, Mass Spectrometry, Analytical Chemistry, Mice, Receptors, GABA, In vivo, Drug Discovery, medicine, Animals, Chromatography, High Pressure Liquid, Solanum tuberosum, Mice, Inbred ICR, Diazepam, Behavior, Animal, Seizure threshold, Plant Extracts, GABAA receptor, Chemistry, Alkaloid, fungi, Organic Chemistry, food and beverages, Anticonvulsant, Complementary and alternative medicine, Biochemistry, Molecular Medicine, Anticonvulsants, Flunitrazepam, medicine.drug |
| الوصف: | Naturally occurring benzodiazepines have been identified in regular food such as wheat and potato, but there is still no evidence that potato extracts can affect CNS responses in vivo. Here we found that undiluted potato juice and potato juice diluted with saline 1 : 2 administered 10 min intracisternally ( I. C.) and 30 min per os before bicuculline exerted significant anticonvulsant activity in the bicuculline-induced seizure threshold test in mice. In vitro, potato juice from different harvests at dilution series from 10 % to 0.000001 %, diluted 100,000-fold, displaced 50 % of gamma-aminobutyric acid (GABA) receptor ligand [ (3)H]GABA and diluted 40-fold displaced 50 % of [(3)H]flunitrazepam from binding sites in mice forebrain membranes. The low content of diazepam (0.04 +/- 0.01 mg/kg) determined by HPLC and mass spectrometry in the potato extracts could not sustain the anticonvulsant activity of potato juice in vivo; therefore we hypothesized that potato juice might contain GABA (A) receptor GABA-site active compounds. The findings of this study suggest that potato juice as well as potato taken as food may have the capacity of influencing brain GABA-ergic activity. |
| تدمد: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2008-1074495 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bac67f95b7453bf0f21e6350cf21e0 https://doi.org/10.1055/s-2008-1074495 |
| رقم الانضمام: | edsair.doi.dedup.....00bac67f95b7453bf0f21e6350cf21e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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| DOI: | 10.1055/s-2008-1074495 |