A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Noninvasive Devices and 0.33-mm Microbiopsies
| العنوان: | A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Noninvasive Devices and 0.33-mm Microbiopsies |
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| المؤلفون: | Jennifer Barillas, Christine E Wamsley, Jeffrey M. Kenkel, Yucel Akgul, Thomas Hitchcock, Mikaela Kislevitz, Deniz S. Basci, Vishal Kandagatla |
| المصدر: | Aesthetic Surgery Journal. 41:NP1603-NP1618 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Urology, Cosmetic Techniques, Single Center, Objective assessment, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, Humans, Rejuvenation, Aged, Skin, Transepidermal water loss, biology, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, Skin Aging, Tolerability, Face, 030220 oncology & carcinogenesis, biology.protein, Female, Surgery, Ultrasonography, business, Elastin, Skin elasticity |
| الوصف: | Background Although ablative techniques are the standard of care for the treatment of fine lines and wrinkles, microneedling offers a minimally invasive alternative. Objectives The purpose of this study was to assess the efficacy of microneedling on facial and neck fine lines and wrinkles. Methods Thirty-five subjects between 44 and 65 years old with Fitzpatrick skin types I to IV received 4 monthly microneedling treatments over the face and neck. Subjects returned 1 and 3 months posttreatment. At every visit, high-resolution ultrasonography and optical coherence tomography were performed, and transepidermal water loss and skin elasticity were measured. Microbiopsies (0.33 mm) were collected pretreatment, before the fourth treatment and 3 months posttreatment. Results Thirty-two subjects (30 females, 2 males) completed all 7 visits. Facial dermal and epidermal density increased 101.86% and 19.28%, respectively, from baseline at 3 months posttreatment. Facial elasticity increased 28.2% from baseline at 3 months posttreatment. Facial attenuation coefficient increased 15.65% and 17.33% at 1 and 3 months posttreatment, respectively. At study completion, blood flow at a depth of 300 µm decreased 25.8% in the face and 42.3% in the neck. Relative collagen type III and elastin gene expression was statistically higher 3 months posttreatment. However, total elastin protein levels were unchanged from baseline values. Dermal muscle formation was observed in 58% of biopsies extracted 3 months posttreatment compared with 15.3% at baseline. Conclusions The results illustrate the effects of microneedling treatments. Noninvasive measurements and biopsy data showed changes in skin architecture and collagen/elastin gene expression, suggesting skin rejuvenation, with new extracellular matrix production and muscle formation. Level of Evidence: 3 |
| تدمد: | 1527-330X 1090-820X |
| DOI: | 10.1093/asj/sjab052 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a7c121f358934fd9ed7a125608f482 https://doi.org/10.1093/asj/sjab052 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....00a7c121f358934fd9ed7a125608f482 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1527330X 1090820X |
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| DOI: | 10.1093/asj/sjab052 |