Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria
| العنوان: | Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria |
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| المؤلفون: | Ian Probert, Vitor Ramos, Emilie Guilloud, Virginio Cepas, Clara B. Martins, Flavio Oliveira, Raquel Castelo-Branco, Sara M. Soto, João Morais, Mohamed Mehiri, Mariana Reis, Maria João Correia, Yaiza Gabasa, Vitor Vasconcelos, Joana D. Ferreira, Lília M.A. Santos, Yuly López |
| المساهمون: | Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Biology, Faculty of Sciences, Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa (INESC-ID), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST)-Instituto de Engenharia de Sistemas e Computadores (INESC), Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] (CIIMAR), Universidade do Porto = University of Porto, Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), European Project: 634588,H2020,H2020-BG-2014-2,NOMORFILM(2015), Universidade do Porto, Université Nice Sophia Antipolis (... - 2019) (UNS), Centro Interdisciplinar de Investigação Marinha e Ambiental |
| المصدر: | Antibiotics Antibiotics, 2019, 8 (2), pp.77. ⟨10.3390/antibiotics8020077⟩ Volume 8 Issue 2 Antibiotics, Vol 8, Iss 2, p 77 (2019) Antibiotics, MDPI, 2019, 8 (2), pp.77. ⟨10.3390/antibiotics8020077⟩ Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Cyanobacteria, Cianobacteris, Microorganism, Marine sources, 030106 microbiology, Chlorophyta, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Biochemistry, Microbiology, Article, 03 medical and health sciences, Algae, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Microalgae, Pharmacology (medical), 14. Life underwater, General Pharmacology, Toxicology and Pharmaceutics, Candida albicans, ComputingMilieux_MISCELLANEOUS, biology, lcsh:RM1-950, Biofilm, biology.organism_classification, Antimicrobial, Antibiofilm, 030104 developmental biology, Infectious Diseases, lcsh:Therapeutics. Pharmacology, Biofilms, Bacteria |
| الوصف: | Bacterial biofilms are complex biological systems that are difficult to eradicate at a medical, industrial, or environmental level. Biofilms confer bacteria protection against external factors and antimicrobial treatments. Taking into account that about 80% of human infections are caused by bacterial biofilms, the eradication of these structures is a great priority. Biofilms are resistant to old-generation antibiotics, which has led to the search for new antimicrobials from different sources, including deep oceans/seas. In this study, 675 extracts obtained from 225 cyanobacteria and microalgae species (11 phyla and 6 samples belonging to unknown group) were obtained from different culture collections: The Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC), the Coimbra Collection of Algae (ACOI) from Portugal, and the Roscoff Culture Collection (RCC) from France. The largest number of samples was made up of the microalgae phylum Chlorophyta (270) followed by Cyanobacteria (261). To obtain a large range of new bioactive compounds, a method involving three consecutive extractions (hexane, ethyl acetate, and methanol) was used. The antibiofilm activity of extracts was determined against seven different bacterial species and two Candida strains in terms of minimal biofilm inhibitory concentration (MBIC). The highest biofilm inhibition rates (%) were achieved against Candida albicans and Enterobacter cloacae. Charophyta, Chlorophyta, and Cyanobacteria were the most effective against all microorganisms. In particular, extracts of Cercozoa phylum presented the lowest MBIC50 and MBIC90 values for all the strains except C. albicans. This work was funded by the European Commission under the H2020 program, NoMorFilm Project (Grant Agreement 634588). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-6382 0066-4758 |
| DOI: | 10.3390/antibiotics8020077⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00266570dd709cf6a2a0ce3fac355b5f https://hal.univ-cotedazur.fr/hal-02560498 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....00266570dd709cf6a2a0ce3fac355b5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796382 00664758 |
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| DOI: | 10.3390/antibiotics8020077⟩ |