Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study

التفاصيل البيبلوغرافية
العنوان: Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study
المؤلفون: Antoine Pariente, Marie Tournier, Hélène Verdoux, Pernelle Noize, Fabienne Bazin, Elodie Pambrun, Anne Bénard-Laribière, Bernard Bégaud
المصدر: Pharmacoepidemiology and Drug Safety. 26:162-169
بيانات النشر: Wiley, 2016.
سنة النشر: 2016
مصطلحات موضوعية: education.field_of_study, Benzodiazepine, medicine.medical_specialty, Bromazepam, Epidemiology, business.industry, medicine.drug_class, Incidence (epidemiology), Population, Pharmacoepidemiology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Oxazepam, Alprazolam, medicine, Pharmacology (medical), 030212 general & internal medicine, business, education, Psychiatry, Prazepam, Demography, medicine.drug
الوصف: Purpose To study trends in incident use of benzodiazepines in France between 2006 and 2012. Methods A cross-sectional study repeated yearly was conducted using data from the French national healthcare insurance system. New benzodiazepine users were defined as users without any benzodiazepine dispensing in the year prior to the first dispensing of benzodiazepine in each year. Relative changes in incidence of use were calculated with the year 2006 as reference; confidence intervals for changes were estimated using the bootstrap method. Results Over the study period, the incident use of benzodiazepines decreased from 6.2% to 5.9%; this corresponded to a 5.1% decrease (95%CI: −6.8% to −4.2%) for 2012 compared to 2006. The decrease mainly concerned hypnotics (−15.5%; −21.2% to −15.3%) and appeared more pronounced in people aged 18–44 years. Incident use of anxiolytics remained stable overall during the period (4.0% of the population). Within anxiolytics, incident use of long half-life benzodiazepines (bromazepam, prazepam) decreased in favor of short half-life benzodiazepines (alprazolam, oxazepam). This change concerned patients aged 65–79 and patients aged 80 years and over. Nevertheless, in 2012, nearly one third of incident users aged 65 years and over started a treatment with a long half-life benzodiazepine, mostly bromazepam. Conclusions A limited decrease in incident benzodiazepine use was observed in France between 2006 and 2012 that concerned only hypnotics. Although congruent with recommendations, this improvement appears insufficient with regard to the level of exposure to these drugs in France. New actions especially targeting anxiolytic benzodiazepine use should be undertaken to consolidate these results. Copyright © 2016 John Wiley & Sons, Ltd.
تدمد: 1053-8569
DOI: 10.1002/pds.4123
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fecafa8cee4d19f65991b4c64ae7122c
https://doi.org/10.1002/pds.4123
Rights: CLOSED
رقم الانضمام: edsair.doi...........fecafa8cee4d19f65991b4c64ae7122c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10538569
DOI:10.1002/pds.4123