Hyperthermia Induced by Magnetic Nanoparticles Improves the Effectiveness of the Anticancer Drug cis-Diamminedichloroplatinum
| العنوان: | Hyperthermia Induced by Magnetic Nanoparticles Improves the Effectiveness of the Anticancer Drug cis-Diamminedichloroplatinum |
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| المؤلفون: | Gabriel Lpez-Berestein, Anil K. Sood, Héctor L. Rodríguez-Luccioni, Carlos Rinaldi, Madeline Torres-Lugo, Jason S. Lee, Janet Mendez |
| المصدر: | Journal of Nanoscience and Nanotechnology. 11:4153-4157 |
| بيانات النشر: | American Scientific Publishers, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Hyperthermia, Cisplatin, Materials science, Biomedical Engineering, Hyperthermia Treatment, Bioengineering, General Chemistry, Condensed Matter Physics, medicine.disease, chemistry.chemical_compound, Dextran, chemistry, medicine, Cancer research, Magnetic nanoparticles, General Materials Science, Viability assay, Incubation, IC50, medicine.drug |
| الوصف: | The cytotoxic enhancement of cisplatin by magnetic fluid hyperthermia (MFH) was investigated in human colon adenocarcinoma cells (Caco-2). A nanoparticle platform based on iron oxide functionalized with carboxymethyl dextran was employed to produce heat at the nanoscale. To assess the synergistic effect of hyperthermia and the anticancer drug cis-Diamminedichloroplatinum, commonly known as cisplatin (CIS), cell viability was measured 24, 48, and 72 hours after three different combined hyperthermia and CIS exposure sequences. These included CIS incubation prior to hyperthermia or magnetic fluid hyperthermia, CIS exposure only during hyperthermia or MFH, and additional CIS incubation following hyperthermia or MFH. Additional incubation of CIS after hyperthermia treatment appears to be more effective than prior CIS incubation for both hyperthermia treatments. Viability data also indicated that MFH combined with CIS is significantly more effective than hot water hyperthermia at the same temperature. A CIS concentration an order of magnitude lower than the calculated IC50 was found to be very effective in reducing cell viability. Such dramatic differences suggest that MFH may enhance the passive transport of CIS. |
| تدمد: | 1533-4899 1533-4880 |
| DOI: | 10.1166/jnn.2011.3821 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fd20c94b306ed6041c5a76a3c004e9ab https://doi.org/10.1166/jnn.2011.3821 |
| رقم الانضمام: | edsair.doi...........fd20c94b306ed6041c5a76a3c004e9ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334899 15334880 |
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| DOI: | 10.1166/jnn.2011.3821 |