Realization of 19F MRI oximetry method using perfluorodecalin
| العنوان: | Realization of 19F MRI oximetry method using perfluorodecalin |
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| المؤلفون: | Aleksandra V. Kuznetsova, Denis N. Silachev, Y.A. Pirogov, L. L. Gervits, Mikhail V. Gulyaev, T. I. Danilina |
| المصدر: | Magnetic Resonance Materials in Physics, Biology and Medicine. 32:307-315 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, Brain glioma, Radiological and Ultrasound Technology, medicine.diagnostic_test, Biophysics, Magnetic resonance imaging, Normal values, Mri studies, Selective excitation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nuclear magnetic resonance, Perfluorodecalin, chemistry, In vivo, medicine, Radiology, Nuclear Medicine and imaging, Tumor growth |
| الوصف: | To identify the technical aspects of the potential use of clinically approved perfluorodecalin (PFD, C10F18) for 19F magnetic resonance imaging (MRI) oximetry method at high magnetic field 7.05 T. 19F T1 measurements were made on a set of PFD samples with different oxygen contents (0%, 21%, and 100%) at room (21 °C) and body temperature (37 °C). In vivo MRI studies were carried out on one healthy rat and two rats with C6 brain glioma. The selective excitation of the magnetically equivalent 19F nuclei of CF2 groups of trans-isomer of PFD, which give a doublet at a frequency of about − 140 ppm (in relation the chemical shift of trifluoroacetic acid, which is − 76.55 ppm) should be done for correct implementation of 19F MRI oximetry method. The amount of PFD equal to 30 μl is the optimal for obtaining reliable data on the measured T1 values. In this case, the standard deviation of T1 does not exceed 5%. In vivo MRI studies showed that the values of the partial pressure of oxygen (pO2) decrease from normal values of about 38 mmHg (healthy brain) to almost 0 mmHg at the last stage of tumor growth. The study showed the feasibility of the successful application of PFD for 19F MRI oximetry method. |
| تدمد: | 1352-8661 0968-5243 |
| DOI: | 10.1007/s10334-019-00739-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::faa21c1712ccb8a159c7ab759f4a3d3d https://doi.org/10.1007/s10334-019-00739-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........faa21c1712ccb8a159c7ab759f4a3d3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13528661 09685243 |
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| DOI: | 10.1007/s10334-019-00739-1 |