Low-dose opioid analgesics (Morphine, Fentanyl, and Sufentanil) do not produce profound cardiovascular effects or reduce survival time in a rat model of traumatic hemorrhage
| العنوان: | Low-dose opioid analgesics (Morphine, Fentanyl, and Sufentanil) do not produce profound cardiovascular effects or reduce survival time in a rat model of traumatic hemorrhage |
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| المؤلفون: | Stephanie Marshall, Kathy Ryan, Mariam Calderon, Bryan Connor, Carmen Hinojosa-Laborde, Harold Klemcke |
| المصدر: | Physiology. 38 |
| بيانات النشر: | American Physiological Society, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology |
| الوصف: | Objective: To determine the impact of analgesic doses of opioids on cardiovascular function and survival time in a severe hemorrhage and extremity trauma rat model. Hypothesis: Using opioids for appropriate pain management, not sedation, will not exacerbate the pathophysiological shock process in a model of polytrauma. Background: Morphine has been doctrinally discarded for use in pain management following battlefield hemorrhage due to its effects on cardiovascular suppression. However, the effects of new opioids, Fentanyl and Sufentanil, on cardiovascular function have yet to be fully described. The current study was conducted to evaluate and compare effects of three opioid analgesics on cardiovascular function and survival after severe hemorrhage in conscious rats in the presence of extremity trauma (ET). Methods: Male rats (n=10/group) were randomly assigned to receive either 0.9% saline (S), 2.0 mg/kg morphine (M), 10 μg/kg fentanyl (F) or 1 μg/kg sufentanil (SuF). Two weeks prior to experimentation, rats were surgically implanted with a telemetry unit to measure mean arterial pressure (MAP) and heart rate (HR). A carotid catheter was then placed. After 24 hours, rats were anesthetized briefly to undergo soft tissue injury and fibula fracture. Rats were allowed to awaken, and 90 min later underwent a conscious hemorrhage (~50% of blood volume). At the end of hemorrhage, rats received one dose of either S, M, F, or SuF via the carotid catheter. Rats were observed for a maximum of 4 hr after the start of hemorrhage. Results: From 70 to 195 min after the end of hemorrhage, there was a significant (p≤0.04) decrease in the MAP of M rats relative to that of V rats, while SuF decreased MAP (p≤0.02) only at t=100, 220 and 240 min. There was no significant effect of treatment on HR (p=0.37) throughout the experiment. Neither survival times (p=0.88) nor percent survival (p=1.0) differed between treatment groups. Conclusions: At the analgesic dose previously shown to ameliorate behavioral indices of pain in rats, both M and SuF depressed blood pressure following severe traumatic hemorrhage. Despite this hypotensive effect, none of the opioids tested decreased survival time or survival rate. Funding disclosure: Applied Pain Research Program, US Army Clinical and Rehabilitative Medicine/Joint Program Committee 8, and US Army Combat Casualty Care Research Program, US Army Medical Research and Development Command. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process. |
| تدمد: | 1548-9221 1548-9213 |
| DOI: | 10.1152/physiol.2023.38.s1.5733037 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f9d55272121f9f76407780a73923c718 https://doi.org/10.1152/physiol.2023.38.s1.5733037 |
| رقم الانضمام: | edsair.doi...........f9d55272121f9f76407780a73923c718 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15489221 15489213 |
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| DOI: | 10.1152/physiol.2023.38.s1.5733037 |