The knowledge of Physiology is extremely necessary for a new medical student to understand the basic functions of human body. Traditionally the entire syllabus of Physiology is completed through didactic lectures and practical sessions. In case of lecture the role of learners is passive and there is less or no interaction of the student with teacher. Case based learning is one of the innovative teaching-learning methodology which can make this subject interesting, clinically useful, and can enable the students to learn it by correlating with its clinical aspects. Cases are generally written as problems that provide the student with a background of a patient or other clinical situation. Supporting information is provided, such as latest research articles, vital signs, clinical signs and symptoms, and laboratory results. CBL allows students to develop a collaborative, team based approach to their education.