THE EFFECT OF SILDENAFIL ON APOMORPHINE-EVOKED INCREASES IN INTRACAVERNOUS PRESSURE IN THE AWAKE RAT
| العنوان: | THE EFFECT OF SILDENAFIL ON APOMORPHINE-EVOKED INCREASES IN INTRACAVERNOUS PRESSURE IN THE AWAKE RAT |
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| المؤلفون: | Jeremy B. Tuttle, Hakan Gemalmaz, Terence N. Chapman, Kristian Waldeck, William D. Steers, Karl-Erik Andersson |
| المصدر: | Journal of Urology. 161:1707-1712 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | business.industry, Sildenafil, Urology, Intracavernous pressure, Tonic (physiology), Apomorphine, chemistry.chemical_compound, Animal model, Pharmacokinetics, chemistry, Anesthesia, Pressure increase, Sprague dawley rats, medicine, business, medicine.drug |
| الوصف: | Purpose: The aim of this study was to develop a quantitative, awake animal model to investigate the effect of sildenafil on centrally-evoked erectile activity.Methods: Intracavernous pressures were recorded in awake, male Sprague Dawley rats after administration of apomorphine (100 or 250 micro g./kg. subcutaneously). Sildenafil (100 micro g./kg. intravenously) was then given 10 min. after a second dose of apomorphine. The time to first response, duration of response, and peak intracavernous pressure and area under the response, were measured before and after sildenafil.Results: Apomorphine produced rhythmic increases in intracavernous pressure. The pressure increase consisted of two components. The amplitude of the first, tonic response was 58 +/− 3 mm. Hg, and a superimposed, burst-like increase in pressure elevated this further to 81 +/− 6 mm. Hg. Bilateral transection of the pudendal nerves abolished the burstlike pressure changes; bilateral transection of the cavernous nerves prevented both r... |
| تدمد: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(05)69009-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f7fb04ac823719949be443bd291f3ef9 https://doi.org/10.1016/s0022-5347(05)69009-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........f7fb04ac823719949be443bd291f3ef9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273792 00225347 |
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| DOI: | 10.1016/s0022-5347(05)69009-x |