Absolute bioavailability of letrozole in healthy postmenopausal women
| العنوان: | Absolute bioavailability of letrozole in healthy postmenopausal women |
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| المؤلفون: | H. Howald, F. Marfil, J. M. Cardot, Antoine Sioufi, N. Gauducheau, F. Vreeland, V. Pineau, J. Godbillon, C. Czendlik, Ch. Pfister, A. Jaouen |
| المصدر: | Biopharmaceutics & Drug Disposition. 18:779-789 |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, biology, business.industry, Letrozole, Metabolite, Pharmaceutical Science, General Medicine, Urine, medicine.disease, Bioavailability, Menopause, chemistry.chemical_compound, Endocrinology, chemistry, Pharmacokinetics, Oral administration, Internal medicine, medicine, biology.protein, Pharmacology (medical), Aromatase, business, medicine.drug |
| الوصف: | Letrozole is a new non-steroidal inhibitor of the aromatase enzyme system. It is currently under development for the treatment of postmenopausal women with advanced breast cancer. Absolute bioavailability of letrozole when given orally as one 2.5 mg film-coated tablet in comparison to the same dose given intravenously as a bolus injection was studied in 12 healthy postmenopausal women. Letrozole absolute systemic bioavailability after p.o. administration was 99.9 +/- 16.3%. Elimination of letrozole was slow. Total-body clearance of letrozole from plasma after i.v. administration was low (2.21 L h-1). The calculated distribution volume at steady state (1.87 L kg-1) suggests a rather high tissue distribution. Biotransformation of letrozole is the main elimination mechanism with the glucuronide conjugate of the secondary alcohol metabolite being the predominant species found in urine. The two study treatments were tolerated equally well. |
| تدمد: | 1099-081X 0142-2782 |
| DOI: | 10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f6afe1b37ed233501529ab3a39555cab https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........f6afe1b37ed233501529ab3a39555cab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1099081X 01422782 |
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| DOI: | 10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5 |