Formulation and Characterization of Ziprasidone Floating Pellets
| العنوان: | Formulation and Characterization of Ziprasidone Floating Pellets |
|---|---|
| المؤلفون: | J Praveen Kumar, S Harika |
| المصدر: | Journal of Biomedical and Pharmaceutical Research. 11 |
| بيانات النشر: | CAB PUBLISHER, 2022. |
| سنة النشر: | 2022 |
| الوصف: | The objective of this study is to design and evaluate Ziprasidone Floating pellets, which prolongs the release rate of the drug while extending the residence time of the drug within the body environment and without causing undeliterious effects to the subject. Ziprasidone and controlled matrix polymer granules were prepared by different granulation techniques in the ratio of 1:1, 1:1.5 and 1:2.Ziprasidone multi unit formulations comprising cellulose polymers were prepared by wet granulation technique, where as the Ziprasidone multi unit formulations comprising lipoidal / fatty polymers were prepared by melt granulation technique. Ziprasidone multi unit formulations with drug and polymer proportion as 1:1, F1 and F2 formulations consisting Cellulose polymers HPMC K4M and HPMC K100 respectively were prepared by wet granulation technique. Keywords: Ziprasidone, wet granulation, Floating pellets, melt granulation and polymer. |
| تدمد: | 2279-0594 2589-8752 |
| DOI: | 10.32553/jbpr.v11i1.894 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f4f8a55782e9de8ca3875817d283fcae https://doi.org/10.32553/jbpr.v11i1.894 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........f4f8a55782e9de8ca3875817d283fcae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22790594 25898752 |
|---|---|
| DOI: | 10.32553/jbpr.v11i1.894 |