RONC-12. Evaluation of brain network segregation using resting state functional MRI in pediatric brain tumor patients treated with proton beam therapy
| العنوان: | RONC-12. Evaluation of brain network segregation using resting state functional MRI in pediatric brain tumor patients treated with proton beam therapy |
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| المؤلفون: | Anna Dowling, Benjamin Seitzman, Timothy Mitchell, Michael Olufawo, Miriam Agamah, Rachel Butler, Alana McMichael, Donna Dierker, Hari Anandarajah, Ally Dworetsky, Rebecca Coalson, Catherine Jiang, Hongjie Gu, Dennis Barbour, Bradley Schlaggar, David Limbrick, Jennifer Strahle, Joshua Rubin, Joshua Shimony, Stephanie Perkins |
| المصدر: | Neuro-Oncology. 24:i179-i179 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Oncology, Neurology (clinical) |
| الوصف: | INTRODUCTION: Mechanisms of cognitive injury in pediatric brain tumor (BT) patients are poorly understood and biomarkers predicting cognitive deficits are lacking. Resting state functional MRI (rsfMRI) can evaluate large-scale brain networks to provide insight into neural changes that follow diagnosis and treatment. This project evaluated functional brain network segregation in pediatric BT patients treated with proton beam radiation therapy (PBRT). METHODS: rsfMRI scans were acquired from 21 pediatric patients (5 female, 16 male) with any brain tumor diagnosis treated with PBRT. Data were processed to reduce contamination, and correlation matrices were generated using all gray matter voxels. Brain network segregation (BNS) was measured and compared to 139 age-matched controls. Analysis included comparison of BNS in association systems (comprised of default mode, frontoparietal, dorsal attention, language, salience, and cingulo-opercular networks) and somatosensory systems (including auditory, visual, and somatomotor networks). Patient and clinical factors were evaluated for relationships with BNS. Patients underwent cognitive testing utilizing the NIH Toolbox Cognitive Domain (NIH-TCD). RESULTS: Median age at PBRT was 10 years (range 2.2-17.9). PBRT volume was whole brain in 10 and conformal in 11. rsfMRI occurred at a median of 2.9 years (range 1.0-5.6) after PBRT. Average BNS of association systems was significantly lower in patients than in controls (t= -8.1, p |
| تدمد: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/noac079.666 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f3c759a8f8ec1c00d06ed6b96103665e https://doi.org/10.1093/neuonc/noac079.666 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........f3c759a8f8ec1c00d06ed6b96103665e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15235866 15228517 |
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| DOI: | 10.1093/neuonc/noac079.666 |