Nevirapine (NVP) Resistance in Women with HIV‐1 Subtype C, Compared with Subtypes A and D, after the Administration of Single‐Dose NVP
| العنوان: | Nevirapine (NVP) Resistance in Women with HIV‐1 Subtype C, Compared with Subtypes A and D, after the Administration of Single‐Dose NVP |
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| المؤلفون: | Susan A. Fiscus, Philippa Musoke, Sarah E. Hudelson, Shu Chen, J. Brooks Jackson, Laura Guay, Newton Kumwenda, Francis Mmiro, Taha E. Taha, Susan H. Eshleman, Donald R. Hoover, Anthony Mwatha |
| المصدر: | The Journal of Infectious Diseases. 192:30-36 |
| بيانات النشر: | Oxford University Press (OUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Nevirapine, biology, virus diseases, Drug resistance, Odds ratio, biology.organism_classification, Resistance mutation, Virology, Zidovudine, Infectious Diseases, immune system diseases, Internal medicine, Lentivirus, Genotype, medicine, Immunology and Allergy, Viral load, medicine.drug |
| الوصف: | Objective. In the Human Immunodeficiency Virus (HIV) Network for Prevention Trials (HIVNET) 012 trial in Uganda, 6-8 weeks after single-dose nevirapine (SD-NVP), NVP resistance mutations were detected at a higher rate in women with HIV-1 subtype D than in women with subtype A. Here, we evaluate the rate of NVP resistance mutations in women with subtype C. Methods. NVP resistance mutations were detected using the ViroSeq HIV-1 Genotyping System. Results. The portion of women with any NVP resistance mutation was higher in those with subtype C (45/ 65 [69.2%] in the NVP and zidovudine trial, Malawi) than in those in the HIVNET 012 trial with either subtype A (28/144 [19.4%]; P |
| تدمد: | 1537-6613 0022-1899 |
| DOI: | 10.1086/430764 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f353b60cb64fcd38a84dd82e585f6c9b https://doi.org/10.1086/430764 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........f353b60cb64fcd38a84dd82e585f6c9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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| DOI: | 10.1086/430764 |