The cystic lesions that affect the oral and maxillofacial region are predominantly odontogenic in origin. The odontogenic cell rests entangled within tissue of the jaws such as cell rests of Malassez, cell rests of serre, and enamel organ leads to its formation. The factors leading to the enlargement of these jaw cysts are increased the permeability of cyst wall, increased the protein content of the cyst fluid, and when the intracystic fluid pressure on the jaw bone is increased. This review is an attempt to analyze and compare the components of cystic fluids such as albumin, prealbumin, globulin, and total protein content among various odontogenic cysts.