Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom
| العنوان: | Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom |
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| المؤلفون: | A. B. Soliev, Sh. I. Salikhov, N. I. Zakirova, A. Yu. Abramov, Z. A. Khushbaktova, M. S. Tashmukhamedov, I. V. Usanova, Vladimir Nikolaevich Syrov, F. G. Kamaev, Sh. Ya. Mirzaakhmedov |
| المصدر: | Pharmaceutical Chemistry Journal. 41:600-604 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Pharmacology, Chromatography, biology, Stereochemistry, Bufalin, Biological activity, Venom, Toad, Nuclear magnetic resonance spectroscopy, High-performance liquid chromatography, Arenobufagin, chemistry.chemical_compound, chemistry, biology.animal, Drug Discovery, Chemical composition |
| الوصف: | The chemical composition of bufadienolides isolated from the venom of Bufo viridis green toad occurring in Central Asia was determined and their biological properties were studied. Six individual bufadienolides were isolated by reverse-phase chromatography on a Lichrosorb RP-8 (10 µ) column in amounts sufficient for qualitative analysis. Two of these were previously identified as arenobufagin and gamabufotalin by NMR spectroscopy and x-ray diffraction methods. The chemical structures of four other bufadienolides are now established by NMR spectroscopy and HPLC. These compounds have been identified as telocinobufagin (3β,5β,14β-trihydroxybufa-20,22-dienolide), marinobufagin (3β, 5β-hydroxy-14,15β-epoxybufa-20,22-dienolide), bufarenogin (3β,12β,14β-hydroxybufa-20,22-dienolide), and bufalin (3β,14β-hydroxybufa-20,22-dienolide). |
| تدمد: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-008-0024-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ed885a26c808ebb058838224fa991f5f https://doi.org/10.1007/s11094-008-0024-y |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........ed885a26c808ebb058838224fa991f5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15739031 0091150X |
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| DOI: | 10.1007/s11094-008-0024-y |