Abstracts PDS
| العنوان: | Abstracts PDS |
|---|---|
| المؤلفون: | John Lakoumentas, Joana Costa, Murilo Luiz Bazon, Inês Pádua, Evgeniia Korotchenko, Isabel Mafra, Caterina Villa, Rita Amaral, Alma Yuste |
| المصدر: | Allergy. 74:130-331 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Spirometry, medicine.medical_specialty, biology, medicine.diagnostic_test, Receiver operating characteristic, Athletes, business.industry, Immunology, Area under the curve, respiratory system, medicine.disease, biology.organism_classification, respiratory tract diseases, Internal medicine, Wheeze, Exhaled nitric oxide, medicine, Cardiology, Immunology and Allergy, Bronchoconstriction, medicine.symptom, business, Asthma |
| الوصف: | Background: Exercise-induced bronchoconstriction (EIB) is a common cause of breathing difficulty in athletes. Fractional exhaled nitric oxide (FeNO) is an indirect marker of airway inflammation, recommended for the assessment and management of asthma; however, the role of FeNO in detecting and monitoring EIB has yet to be fully established. The aim of this study was therefore to evaluate the predictive value of FeNO to confirm or refute EIB in athletes presenting with exertional dyspnoea. Method: Seventy athletes (male: n = 45) (age: 35 ± 11 years) reporting respiratory symptoms (i.e. wheeze, cough and dyspnoea) during exercise attended the laboratory on a single occasion. All athletes performed resting FeNO and spirometry pre-and-post a eucapnic voluntary hyperpnoea challenge (EVH) in accordance with international guidelines. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for established FeNO thresholds: (intermediate [≥25ppb] and high [>50ppb]) and evaluated against objective evidence of EIB: (EVH diagnostic cut-off [-10% ΔFEV1 at two consecutive time-points] and [-15% ΔFEV1 at one time-point]). The diagnostic accuracy of FeNO was calculated using receiver operating characteristics area under the curve (ROC-AUC). Results: All had normal resting lung function (>80% FEV1 pred). The prevalence of EIB was 33% (-10% ΔFEV1) and 23% (-15% ΔFEV1) (median (IQR) ΔFEV1 = -7% (10.02)). FeNO values ≥25ppb and >50ppb were observed in 49% and 23% of the cohort, respectively. ROC-AUC for FeNO was 75% (-10% ΔFEV1) and 86% (-15% ΔFEV1). Sensitivity, specificity, PPV and NPV are presented in Table 1. Conclusion: Our findings indicate that FeNO >50ppb provides good specificity for a positive EVH test; however, should not replace indirect bronchoprovocation for diagnostic purposes. The high proportion of athletes reporting breathing difficulty in the absence of EIB highlights the requirement to consider alternative causes of exertional dyspnoea during clinical work-up. |
| تدمد: | 1398-9995 0105-4538 |
| DOI: | 10.1111/all.13959 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::eb85ac28522b797025deeb5de9c1cee0 https://doi.org/10.1111/all.13959 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........eb85ac28522b797025deeb5de9c1cee0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13989995 01054538 |
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| DOI: | 10.1111/all.13959 |