Degradation of intestinal glycoproteins byBacteroides vulgatus
| العنوان: | Degradation of intestinal glycoproteins byBacteroides vulgatus |
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| المؤلفون: | L. M. C. Van Lieshout, J. G. H. Ruseler-Van Embden, R. van der Helm |
| المصدر: | FEMS Microbiology Letters. 58:37-41 |
| بيانات النشر: | Oxford University Press (OUP), 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Antigenicity, Crohn's disease, biology, food and beverages, biology.organism_classification, medicine.disease, Microbiology, Mucus, Pathogenesis, fluids and secretions, Enzyme, chemistry, Genetics, medicine, Bacteroides, Glycoprotein, Molecular Biology, Bacteroidaceae |
| الوصف: | Bacteroides vulgatus, isolated from a patient with Crohn's disease, produced in gnotobiotic rats 7 constitutive enzymes that might be concerned with the degradation of intestinal glycoproteins. Furthermore Bacteroides vulgatus caused an almost complete loss of blood group antigenicity of the intestinal glycoproteins. Enzymes with the potency to release toxic compounds from hepatic conjugates and plant glycosides, β-glucuronidase and β-glucosidase, respectively, were only detectable in small amounts. These findings indicate that Bacteroides vulgatus, which accounts for 40% of the total flora of patients with Crohn's disease, may play a role in the pathogenesis of Crohn's disease, by increasing the break-down of the mucus layer and therefore damaging its protective function. |
| تدمد: | 1574-6968 0378-1097 |
| DOI: | 10.1111/j.1574-6968.1989.tb03014.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::eb2cb6334fbe37fbb00497e3f31fa3c4 https://doi.org/10.1111/j.1574-6968.1989.tb03014.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........eb2cb6334fbe37fbb00497e3f31fa3c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15746968 03781097 |
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| DOI: | 10.1111/j.1574-6968.1989.tb03014.x |