Central lines can be placed in several locations, most commonly internal jugular or femoral. Subclavian central lines are less common due to concern for iatrogenic pneumothorax. However, they are an important skill because there are situations in which internal jugular and femoral access are not available. Subclavian central lines are typically placed without ultrasound using anatomical landmarks. Special precautions are taken to minimize the risk of pneumothorax, secondary to accidental pleural puncture, and hemothorax, secondary to unintentional puncture of the subclavian artery. This chapter outlines equipment, positioning, and instructions for placing a subclavian central line without ultrasound using anatomical landmarks.