Bioprospecting of Novel and Bioactive Metabolites from Endophytic Fungi Isolated from Rubber Tree Ficus elastica Leaves
| العنوان: | Bioprospecting of Novel and Bioactive Metabolites from Endophytic Fungi Isolated from Rubber Tree Ficus elastica Leaves |
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| المؤلفون: | Jun Han, Lili Wang, Huiming Huang, Zhuang Ding, Zhengping Wang, Tao Tao, Min Liu, Demeng Zhang, Yanna Zhao |
| المصدر: | Journal of Microbiology and Biotechnology. 29:731-738 |
| بيانات النشر: | Journal of Microbiology and Biotechnology, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0106 biological sciences, Microorganism, Trichoderma harzianum, General Medicine, Ficus elastica, Biology, medicine.disease_cause, biology.organism_classification, Antimicrobial, 01 natural sciences, Applied Microbiology and Biotechnology, Plant use of endophytic fungi in defense, Isocoumarin, chemistry.chemical_compound, chemistry, 010608 biotechnology, Botany, medicine, Penicillium funiculosum, Escherichia coli, Biotechnology |
| الوصف: | Endophytic fungi are an important component of plant microbiota, and have the excellent capacity for producing a broad variety of bioactive metabolites. These bioactive metabolites not only affect the survival of the host plant, but also provide valuable lead compounds for novel drug discovery. In this study, forty-two endophytic filamentous fungi were isolated from Ficus elastica leaves, and further identified as seven individual taxa by ITS-rDNA sequencing. The antimicrobial activity of these endophytic fungi was evaluated against five pathogenic microorganisms. Two strains, Fes1711 (Penicillium funiculosum) and Fes1712 (Trichoderma harzianum), displayed broad-spectrum bioactivities. Our following study emphasizes the isolation, identification and bioactivity testing of chemical metabolites produced by T. harzianum Fes1712. Two new isocoumarin derivatives (1 and 2), together with three known compounds (3-5) were isolated, and their structures were elucidated using NMR and MS. Compounds 1 and 2 exhibited inhibitory activity against Escherichia coli. Our findings reveal that endophytic fungi from the rubber tree F. elastica leaves exhibit unique characteristics and are potential producers of novel natural bioactive products. |
| تدمد: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1901.01015 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e7f5f90b090f8a29387f0474a0d6b3c7 https://doi.org/10.4014/jmb.1901.01015 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........e7f5f90b090f8a29387f0474a0d6b3c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17388872 10177825 |
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| DOI: | 10.4014/jmb.1901.01015 |