Complete essential oils of Laurus nobilis inducing antinociceptive action by opioid mechanism in C-Reflex and spinal Wind-Up model in rat

التفاصيل البيبلوغرافية
العنوان: Complete essential oils of Laurus nobilis inducing antinociceptive action by opioid mechanism in C-Reflex and spinal Wind-Up model in rat
المؤلفون: Claudio Laurido, Bernardo Morales, Carlos Valdes, Luisauris Jaimes, José Luis Martínez, Raúl Vinet
المصدر: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 19:420-427
بيانات النشر: MS-Editions, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Pharmacology, Traditional medicine, Chemistry, Plant Science, (+)-Naloxone, food.food, law.invention, Laurus nobilis, food, Nociception, Complementary and alternative medicine, law, Drug Discovery, Reflex, Essential oil
الوصف: The essential oil of Laurus nobilis L. was used to test their antinociceptive efficacy. It was applied intraperitoneally (i.p.) to rats subjected to a nociception test (C reflex and spinal wind-up). The results showed that the essential oil applied at higher doses (0.06 mg/Kg) causes a complete abolition of the spinal wind-up, while the C reflex was unchanged, indicating a clear antinociceptive effect. At lower concentrations (0.012 mg/Kg), there was a lowering in the wind-up by 85% within ten minutes of the essential i.p. oil application. Interestingly, there was an effect of naloxone (0.08 mg/Kg i.p.) When applied, a change occurs that almost entirely reversed the antinociception caused by the essential oil from Laurus nobilis. We conclude that there is a significant antinociceptive effect of the essential oil of Laurus nobilis subjected to electric nociception. In addition, it was observed that naloxone reversed the antinociceptive effect (windup) produced by Laurus nobilis.
تدمد: 0717-7917
DOI: 10.37360/blacpma.20.19.4.29
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e57f734f3bb8bf122739d38282672de4
https://doi.org/10.37360/blacpma.20.19.4.29
Rights: OPEN
رقم الانضمام: edsair.doi...........e57f734f3bb8bf122739d38282672de4
قاعدة البيانات: OpenAIRE
الوصف
تدمد:07177917
DOI:10.37360/blacpma.20.19.4.29