Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
| العنوان: | Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin |
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| المؤلفون: | Paul S. Maddox, Amy Bejsovec, Brooke M. McCartney, Elizabeth E. Grevengoed, Mark Peifer, Donald G. McEwen |
| المصدر: | Nature Cell Biology. 3:933-938 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | animal structures, integumentary system, Cell division, Cell Biology, Biology, Cell biology, Microtubule, biology.animal, embryonic structures, Armadillo, Cytoskeleton, Astral microtubules, Multipolar spindles, Mitosis, Actin |
| الوصف: | Proper positioning of mitotic spindles ensures equal allocation of chromosomes to daughter cells. This often involves interactions between spindle and astral microtubules and cortical actin1. In yeast and Caenorhabditis elegans, some of the protein machinery that connects spindles and cortex has been identified but, in most animal cells, this process remains mysterious. Here, we report that the tumour suppresser homologue APC2 and its binding partner Armadillo both play roles in spindle anchoring during the syncytial mitoses of early Drosophila embryos. Armadillo, α-catenin and APC2 all localize to sites of cortical spindle attachment. APC2–Armadillo complexes often localize with interphase microtubules. Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2–Armadillo complexes. Together, these data suggest that APC2, Armadillo and α-catenin provide an important link between spindles and cortical actin, and that this link is regulated by Zeste-white 3 kinase. |
| تدمد: | 1476-4679 1465-7392 |
| DOI: | 10.1038/ncb1001-933 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e2efbc89e74bbd53f5964b8a96ad3d88 https://doi.org/10.1038/ncb1001-933 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........e2efbc89e74bbd53f5964b8a96ad3d88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764679 14657392 |
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| DOI: | 10.1038/ncb1001-933 |