Abstract 13398: 4D Flow Cardiac MRI Reveals Subtle Diastolic Dysfunction in Young Adults Born Premature
| العنوان: | Abstract 13398: 4D Flow Cardiac MRI Reveals Subtle Diastolic Dysfunction in Young Adults Born Premature |
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| المؤلفون: | Christopher J. François, Oliver Wieben, Marlowe W. Eldridge, Philip A. Corrado, Jacob A. Macdonald, Kara N. Goss |
| المصدر: | Circulation. 142 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Born premature, Diastole, Cardiology, Medicine, Young adult, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Introduction: Individuals born premature have smaller ventricular chambers volumes and a reduced cardiac reserve during exercise. Epidemiologic studies demonstrate increased risk of developing heart failure by young adulthood, though whether this is due primarily to systolic or diastolic dysfunction remains unresolved. Hypothesis: We hypothesize that either systolic or diastolic function, quantified as intraventricular kinetic energy (KE) during systolic and diastolic phases, respectively, will be altered in both ventricles of young adults born premature. Methods: A total of 56 young adults participated in this observational cardiac MRI study: 35 subjects born moderately to extremely premature (birth weight Results: Average KE/EDV and peak systolic KE/EDV were similar between term and preterm subjects. Preterm-born subjects had increased A-wave KE/EDV in the RV and decreased E/A KE ratio in both ventricles (Table 1), indicating subtle diastolic dysfunction. The E/A KE ratio was moderately correlated with stroke volume index in both ventricles (LV: R=0.37, P=0.005; RV: R=0.32, P=0.02). Conclusions: Our results suggest that diastolic dysfunction, along with reduced chamber size, contributes to the reduced stroke volume seen in individuals born premature. In addition, diastolic dysfunction may further limit cardiac functional reserve and increase early heart failure risk in this population. |
| تدمد: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.142.suppl_3.13398 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e1e3b154faf6ed9e7c64c2fb94619788 https://doi.org/10.1161/circ.142.suppl_3.13398 |
| رقم الانضمام: | edsair.doi...........e1e3b154faf6ed9e7c64c2fb94619788 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
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| DOI: | 10.1161/circ.142.suppl_3.13398 |