التفاصيل البيبلوغرافية
| العنوان: |
Follicular variant papillary thyroid carcinoma in a pediatric population |
| المؤلفون: |
Melanie Goldfarb, Jonathan Lerner |
| المصدر: |
Pediatric Blood & Cancer. 62:1942-1946 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Oncology, medicine.medical_specialty, Pathology, business.industry, Hazard ratio, Histology, Hematology, Odds ratio, medicine.disease, Thyroid carcinoma, Internal medicine, Pediatrics, Perinatology and Child Health, Follicular phase, Carcinoma, Medicine, business, Thyroid cancer, Survival rate |
| الوصف: |
Background Follicular variant of papillary thyroid carcinoma (FVPTC) has been shown to be an intermediate entity between papillary (PTC) and follicular/Hurtle cell (FTC) thyroid carcinoma in adults. However, the tumor characteristics and prognosis of FVPTCs has not been studied in the pediatric population and is the focus of the current study Methods All pediatric patients ≤19 years of age with differentiated thyroid cancer (PTC, FVPTC, or FTC) were identified from the SEER registry from 1988–2009. Patients were divided into groups based on their histology. Adjusted odds ratios (ORs) for demographic, tumor, and treatment characteristics, as well as hazard ratios (HRs) for overall (OS) and disease-specific survival (DSS) were calculated for FVPTC. Results Of 1,956 patients, 445 (22.7%) had FVPTC. Compared to PTCs, FVPTCs were larger (OR: 2.03, CI:1.35–3.06), node negative (OR: 2.26, CI:1.61–3.19), occurred more often in patients 4 cm (HR: 13.92, CI:1.24–156.72) influenced OS for patients with FVPTC. There was no significant difference in OS or DSS between groups. Conclusions In pediatric patients ≤19 years of age, FVPTCs have intermediate tumor features compared to PTC and FTC, but a similar OS and DSS. All pediatric patients with thyroid cancer require lifelong surveillance. However, FVPTCs >4 cm may warrant closer follow-up due to an increased risk of death. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. |
| تدمد: |
1545-5009 |
| DOI: |
10.1002/pbc.25623 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ac5bfaaf3c94ca5efaa87097c80990
https://doi.org/10.1002/pbc.25623 |
| Rights: |
CLOSED |
| رقم الانضمام: |
edsair.doi...........e0ac5bfaaf3c94ca5efaa87097c80990 |
| قاعدة البيانات: |
OpenAIRE |