Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking
| العنوان: | Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking |
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| المؤلفون: | Madeline C. Winkler, Tracey A Larson, Jacob Stafford, Casey E O'Neill, Ryan K. Bachtell, Sophia C Levis |
| المصدر: | Psychopharmacology. 236:1207-1218 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Pharmacology, Agonist, business.industry, medicine.drug_class, Stimulation, Adenosine receptor, Adenosine, 030227 psychiatry, 03 medical and health sciences, Adenosine A1 receptor, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Dopamine receptor D3, Dopamine receptor, Medicine, business, 030217 neurology & neurosurgery, CGS-21680, medicine.drug |
| الوصف: | Previous work has demonstrated that dopamine and adenosine receptors are involved in drug-seeking behaviors, yet the pharmacological interactions between these receptors in methamphetamine (MA) seeking are not well characterized. The present studies examined the role of the dopamine D2-like receptors in MA seeking and identified the interactive effects of adenosine receptor stimulation. Adult male Sprague–Dawley rats were trained to lever press for MA in daily 2-h self-administration sessions on a fixed-ratio 1 schedule for 10 consecutive days. After 1 day of abstinence, lever pressing was extinguished in six daily extinction sessions. Treatments were administered systemically prior to a 2-h reinstatement test session. An increase in MA seeking was observed following the administration of the dopamine D2-like agonist, quinpirole, or the D3 receptor agonist, 7-OH-DPAT. Stimulation of D2 or D4 receptors was ineffective at inducing MA seeking. Quinpirole-induced MA seeking was inhibited by D3 receptor antagonism (SB-77011A or PG01037), an adenosine A1 agonist, CPA, and an adenosine A2A agonist, CGS 21680. MA seeking induced by a MA priming injection or D3 receptor stimulation was inhibited by a pretreatment with the adenosine A1 agonist, CPA, but not the adenosine A2A agonist, CGS 21680. These results demonstrate the sufficiency of dopamine D3 receptors to reinstate MA seeking that is inhibited when combined with adenosine A1 receptor stimulation. |
| تدمد: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-018-5126-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::de3443b86f333ae4b954247066565079 https://doi.org/10.1007/s00213-018-5126-y |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........de3443b86f333ae4b954247066565079 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322072 00333158 |
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| DOI: | 10.1007/s00213-018-5126-y |