Vascular Clogging, Mononuclear Cell Margination, and Enhanced Vascular Permeability in the Pathogenesis of Human Cerebral Malaria
| العنوان: | Vascular Clogging, Mononuclear Cell Margination, and Enhanced Vascular Permeability in the Pathogenesis of Human Cerebral Malaria |
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| المؤلفون: | Damodar Mohanty, Jaya Krishna Patnaik, Sanjib Mohanty, Sanjay Kumar Satpathy, Saroj K. Mishra, Das Bs |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 51:642-647 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Central nervous system, Vascular permeability, Plasmodium falciparum, Biology, Hypoxia (medical), biology.organism_classification, Peripheral blood mononuclear cell, Pathogenesis, Apposition, Infectious Diseases, medicine.anatomical_structure, Cerebral Malaria, Virology, parasitic diseases, Immunology, medicine, Parasitology, medicine.symptom |
| الوصف: | To document histopathologic evidence on the pathogenic mechanism of human cerebral malaria, we used light microscopy to study brain specimens from 23 patients who died of central nervous system involvement with Plasmodium falciparum. Sequestration of parasitized red blood cells (PRBCs) leading to cerebral capillary clogging was seen. In a few specimens, vascular clogging by PRBCs was associated with margination of mononuclear cells. In others, capillaries were virtually empty and lymphocytes and monocytes were seen in apposition (marginated) to the capillary endothelial surface. The endothelial cells appeared plump, hypertrophied, and prominent. The capillary wall appeared thickened by fibrinous material. Massive intercellular brain edema along with extravasated red blood cells, mononuclear cells, and plasmatic fluid was also noticed. In addition to hypoxia induced by PRBC-mediated vascular clogging, marginating mononuclear cells may contribute to the pathogenesis of cerebral malaria. The precise role played by this phenomenon needs further evaluation. |
| تدمد: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1994.51.642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::da9e1e90db486519fadf70020b3f9329 https://doi.org/10.4269/ajtmh.1994.51.642 |
| رقم الانضمام: | edsair.doi...........da9e1e90db486519fadf70020b3f9329 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.1994.51.642 |