Additional value of CMR feature tracking parameters for the evaluation of the risk of complex ventricular arrhythmias and sudden cardiac death in patients with Mitral Valve Prolapse
| العنوان: | Additional value of CMR feature tracking parameters for the evaluation of the risk of complex ventricular arrhythmias and sudden cardiac death in patients with Mitral Valve Prolapse |
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| المؤلفون: | A Pavon, M Guglielmo, D Arangalage, M Bonanni, G Angelini, V Paiocchi, L Leo, M Valgimigli, G Pedrazzini, G Pontone, P Monney, F Faletra |
| المصدر: | European Heart Journal - Cardiovascular Imaging. 23 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Background Mitral valve prolapse (MVP) with mitro-annular disjunction (MAD) has been associated with complex ventricular arrhythmias (c-VA) and sudden cardiac death (SCD) but risk stratification in this subset of patients remains insufficiently characterized. The aim of this study was to investigate the association between deformation parameters assessed by feature tracking (FT) cardiac magnetic resonance (CMR) in patients with MVP and MAD (MVP-MAD) and c-VA and/or SCD. Methods We included 23 patients (47 ± 13 years; 43 % males) with MVP-MAD, of whom 17 (74 %) presented with c-VA and 6 (26%) with SCD, as well as 20 age- and sex-matched controls (50 ± 18 years; 57% males). All patients underwent CMR with assessment of MAD length, late gadolinium enhancement (LGE), extracellular volume (ECV), global and regional longitudinal (LS), and circumferential strain (CS). RATIO-CS was defined as the ratio between regional CS in the basal inferolateral and mid-inferolateral walls (fig.1). Results In MVP-MAD patients, non-ischemic LGE of the LV inferior and inferolateral wall was observed in 21 patients (50%). As compared to controls, MVP-MAD patients showed lower global LS (-18.7 ±4.1 vs -24.7 ± 5.7 p Logistic univariate regression analysis showed an increased risk of c-VA in case of LGE presence (OR: 9.52 [2.28-39.7] p = 0.002), a high number of LV segments with LGE (OR: 1.78 [1.21-2.63] p = 0.004), GLS (OR: 1.58 [1.21-2.07] p Conclusion Lower inferolateral LS and RATIO CS are respectively associated with c-VA and SCD in MVP-MAD patients. FT may provide additional value for risk stratification on top of standard CMR parameters in this subset of patients. Abstract Figure. fig.1 Abstract table 1 |
| تدمد: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeab289.372 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::da23661043da78732aada0db18ba4c8a https://doi.org/10.1093/ehjci/jeab289.372 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........da23661043da78732aada0db18ba4c8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472412 20472404 |
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| DOI: | 10.1093/ehjci/jeab289.372 |