Synthesis and In Vitro Anticancer Evaluation of Chrysin Containing Hybrids and Other Chrysin Derivatives
| العنوان: | Synthesis and In Vitro Anticancer Evaluation of Chrysin Containing Hybrids and Other Chrysin Derivatives |
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| المؤلفون: | Szabolcs Mayer, Dominika Mária Herr, Nóra Nagy, Viktória Donkó-Tóth, Péter Keglevich, Márton Weber, Miklós Dékány, László Hazai |
| المصدر: | Periodica Polytechnica Chemical Engineering. 67:316-336 |
| بيانات النشر: | Periodica Polytechnica Budapest University of Technology and Economics, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Chemical Engineering |
| الوصف: | Chrysin, a well-known naturally occurring flavonoid having several biological effects including antiproliferative activity, was coupled with different pharmacophore structures. Coupling was carried out with spacers of different lengths and types. Structures selected for hybrid formation were amines, cyclic amino acid esters, and (hetero)aromatic compounds. In addition, vindoline, which is a Vinca alkaloid containing an indole skeleton, was also used. The alkylation of amines in the presence of carbonate base resulted in an interesting carbamate side product formation beside the expected amine. We also present the detailed structure elucidation of the carbamates. The in vitro anticancer activities of the synthesized derivatives were examined against 60 human tumor cell lines in National Cancer Institute (NCI, USA). |
| تدمد: | 1587-3765 0324-5853 |
| DOI: | 10.3311/ppch.21919 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::da1335b1908e3708f27bb0e1c3859e96 https://doi.org/10.3311/ppch.21919 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........da1335b1908e3708f27bb0e1c3859e96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15873765 03245853 |
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| DOI: | 10.3311/ppch.21919 |