Maxillofacial reconstruction is complicated due to the etiology and nature of the tissue injury. The complexity of the facial structures adds to the difficulty of rehabilitation both functionally and esthetically. Skeletal reconstruction is by far the easiest part of the rehabilitation. Restoration of soft tissues like skin, cartilage, and mucosa without the support of the underlying bony architecture is possible with prosthesis. Silicone is the most commonly used prosthetic material for maxillofacial rehabilitation. Nanomaterials play an important role in bestowing color compatibility and interface stability in the prosthesis.